2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Randialic acid B

Randialic acid B 是一种三萜化合物，是一种甲酰肽受体 1 (FPR1) 拮抗剂。Randialic acid B 阻断人中性粒细胞中的 FPR1 并在体内减轻银屑病样炎症。

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Randialic acid B Chemical Structure

Randialic acid B Chemical Structure

CAS No. : 14021-14-8

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1 mg ￥2240
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5 mg ￥5760
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10 mg ￥8928
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Customer Review

Randialic acid B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo[1].

体外研究
(In Vitro)

Randialic acid B (0.1-3 μM; for 5 min) selectively inhibits reactive oxygen species production, elastase release, and CD11b expression in human neutrophils activated by FPR1. Randialic acid B inhibits the binding of N-formyl peptide to FPR1 in human neutrophils, neutrophil-like THP-1 cells, and hFPR1-transfected HEK293 cells, indicating FPR1 antagonism[1].
Randialic acid B acts competitively for its binding to the FPR1 receptor. The FPR1-downstream signaling such as Ca2+ mobilisation and activation of Akt and MAPKs is also competitively inhibited[1].
Randialic acid B shows significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Randialic acid B 相关抗体:
体内研究
(In Vivo)

Randialic acid B (10 mg/kg; i.v.; every other day; for 5 days) significantly reduces Imiquimod-induced psoriasis-like symptom, including epidermal hyperplasia, desquamation with scaling, neutrophil skin infiltration, and transepidermal water loss[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c white female mice (20 g weight; 7-week-old) treated with Imiquimod[1]
Dosage: 10 mg/kg
Administration: i.v.; every other day; for 5 days
Result: Significantly reduced Imiquimod-induced psoriasis-like symptoms.
分子量

454.68

Formula

C30H46O3
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (219.93 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1993 mL 10.9967 mL 21.9935 mL
5 mM 0.4399 mL 2.1993 mL 4.3987 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.94%

COA (267 KB) HNMR (297 KB) CNMR (135 KB) RP-HPLC (137 KB) MS (79 KB)

产品使用指南 (1538 KB)
参考文献

Randialic acid B 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1993 mL 10.9967 mL 21.9935 mL 54.9837 mL
5 mM 0.4399 mL 2.1993 mL 4.3987 mL 10.9967 mL
10 mM 0.2199 mL 1.0997 mL 2.1993 mL 5.4984 mL
15 mM 0.1466 mL 0.7331 mL 1.4662 mL 3.6656 mL
20 mM 0.1100 mL 0.5498 mL 1.0997 mL 2.7492 mL
25 mM 0.0880 mL 0.4399 mL 0.8797 mL 2.1993 mL
30 mM 0.0733 mL 0.3666 mL 0.7331 mL 1.8328 mL
40 mM 0.0550 mL 0.2749 mL 0.5498 mL 1.3746 mL
50 mM 0.0440 mL 0.2199 mL 0.4399 mL 1.0997 mL
60 mM 0.0367 mL 0.1833 mL 0.3666 mL 0.9164 mL
80 mM 0.0275 mL 0.1375 mL 0.2749 mL 0.6873 mL
100 mM 0.0220 mL 0.1100 mL 0.2199 mL 0.5498 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Randialic acid B14021-14-8Reactive Oxygen SpeciesFPR1psoriasisanti-inflammationROSelastaseCD11bInhibitorinhibitorinhibit

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