2. Academic Validation
  3. Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against H2O2-induced myocardial cell injury

Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against H2O2-induced myocardial cell injury

  • Chin J Nat Med. 2017 Feb;15(2):115-120. doi: 10.1016/S1875-5364(17)30027-4.
Shan-Shan Li 1,  Yan-Li Liu 2,  Qiong-Ming Xu 3,  Chen-Mei Mao 4,  Shi-Lin Yang 2
Affiliations

Affiliations

  • 1 Children's Hospital of Soochow University, Suzhou 215003, China; College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
  • 2 College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
  • 3 College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China. Electronic address: xuqiongming@suda.edu.cn.
  • 4 Children's Hospital of Soochow University, Suzhou 215003, China. Electronic address: maocm68@163.com.
PMID: 28284425 DOI: 10.1016/S1875-5364(17)30027-4
Abstract

In the present study, three new triterpenoids, 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-α-L-arabinopyranoside (1), 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (2), and urs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (3), and a known triterpenoid, 3β-hydroxy-urs-2, 18-dien-28-oic acid (4, randialic acid B), were isolated from the aerial parts of Ilex cornuta. Their structures were identified by the spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR) and chemical reactions. Compound 4 showed significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury. Compounds 1-4 did not show any significant DPPH radical scavenging activity.

Keywords

Aquifoliaceae; Cardiomyocytes Oxidative injury; Ilex cornuta; Triterpenoids.

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