2. 重组蛋白
  3. Enzymes & Regulators
  4. Hydrolases (EC 3) ADAMs/ADAMTSs
  5. ADAM12
  6. ADAM12 蛋白, Mouse (Baculovirus, His-Myc)

ADAM12 蛋白, Mouse (Baculovirus, His-Myc)

目录号: HY-P72061
产品使用指南

ADAM12 蛋白, Mouse (Baculovirus, His-Myc) 是一种分解素和金属蛋白酶。ADAM12 在上皮癌中上调，并有助于增加肿瘤增殖、转移和内分泌抵抗。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

ADAM12 Protein, Mouse (Baculovirus, His-Myc) is a disintegrin and a metalloprotease. ADAM12 is upregulated in epithelial cancers and contributes to increased tumor proliferation, metastasis, and endocrine resistance.
研究背景

ADAM12（一种解整合素和金属蛋白酶）在乳腺癌、前列腺癌、卵巢癌、皮肤癌、胃癌、肺癌和脑癌中表达上调。人 ADAM12 可以表达为两种交替剪接变体：膜相关 ADAM12-L 和较短的分泌型 ADAM12-S。两种亚型分别由前体、金属蛋白酶、解整合素和富含半胱氨酸的结构域以及非同源的细胞质尾组成。ADAM12-L 具有跨膜区域。ADAM12 在原位和转基因肿瘤模型中通过促进肿瘤细胞增殖、迁移和侵袭、诱导肿瘤细胞抵抗凋亡、促进内分泌抵抗和增强恶性肿瘤-间质串扰来促进肿瘤进展和转移[1][2]。
种属

Mouse
表达系统

Sf9 insect cells
标签

N-10*His;C-Myc
蛋白编号

Q61824 (E206-G706)
基因 ID

11489  [NCBI]
蛋白结构
N-term
10*His
ADAM12 (E206-G706)
Accession # Q61824
Myc
C-term
同用名
Adam12; MltnaDisintegrin and metalloproteinase domain-containing protein 12; ADAM 12; EC 3.4.24.-; Meltrin-alpha
氨基酸序列

ETLKMTKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDIDKCSISQDPFTSLHEFLDWRKIKLLPRKSHDNAQLISGVYFQGTTIGMAPIMSMCTAEQSGGVVMDHSDSPLGAAVTLAHELGHNFGMNHDTLERGCSCRMAAEKGGCIMNPSTGFPFPMVFSSCSRKDLEASLEKGMGMCLFNLPEVKQAFGGRKCGNGYVEEGEECDCGEPEECTNRCCNATTCTLKPDAVCAHGQCCEDCQLKPPGTACRGSSNSCDLPEFCTGTAPHCPANVYLHDGHPCQGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKSAFAKCELRDAKCGKIQCQGGASRPVIGTNAVSIETNIPQQEGGRILCRGTHVYLGDDMPDPGLVLAGTKCAEGKICLNRRCQNISVFGVHKCAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQG

分子量

Approximately 58.4 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
参考文献

ADAM12 Protein, Mouse (Baculovirus, His-Myc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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