1. 重组蛋白
  2. Receptor Proteins
  3. AGER 蛋白, Human (HEK293, His)

AGER 蛋白, Human (HEK293, His)

目录号: HY-P7467
COA 产品使用指南

AGER 蛋白, Human (HEK293, His)是带有 C 末端 His 标签的人重组 AGER,通过哺乳动物表达系统表达,并表达编码Ala23-Ala344的靶基因。

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规格 价格 是否有货 数量
10 μg ¥900 In-stock
50 μg ¥2500 In-stock
100 μg   询价  

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描述

AGER Protein, Human (HEK293, His) is human recombinant AGER with a His tag at the C-terminus. AGER Protein, Human (HEK293, His) is expressed by mammalian expression system and the target gene encoding Ala23-Ala344 is expressed.

研究背景

AGER(高级糖基化终产物特异性受体)是细胞表面分子免疫球蛋白超家族的成员,是一种跨膜信号转导受体,具有许多配体,包括可以启动和维持免疫反应的警报素。AGER 天然以两种形式存在,即全长膜结合形式和截短(可溶)形式。人类 AGER 是一个高度多态性的基因,其位于 6p21.3 染色体上的基因座有超过 190 个 SNP。AGER 与多种配体和多种信号通路相互作用,例如由高迁移率族盒 1 (HMGB1) 蛋白(AGER 的非经典配体)激活的信号通路。在动脉粥样硬化等某些疾病中,AGER 是急性和慢性血管炎症的介质,尤其是糖尿病的并发症[1][2]

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

Q15109 (A23-A344)

基因 ID

177  [NCBI]

蛋白结构
N-term
AGER (A23-A344)
Accession # Q15109
6*His
C-term
中文名
重组人 AGER,His (HEK293 细胞表达)
同用名
rHuAGER, His; RAGE; AGER
氨基酸序列

AQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALAHHHHHH

分子量

Approximately 55.0 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料
参考文献

AGER Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
AGER Protein, Human (HEK293, His)
目录号:
HY-P7467
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