AHSG/Fetuin-A 蛋白, Mouse (HEK293, His)

AHSG/Fetuin-A Protein, Mouse (HEK 293, His), a phosphorylated glycoprotein, it is synthesized mainly by the liver parenchyma cells.

Fetuin-A 也是一种多功能血浆剂。胎球蛋白-A 作为与胰岛素抵抗相关的胰岛素受体酪氨酸激酶的生理抑制剂和负性急性期反应物发挥作用。它还调节骨重塑和钙代谢，是钙盐沉淀和血管钙化的重要抑制剂。尽管它目前被认为是一种多功能蛋白质，但它在糖尿病和肾脏疾病等疾病过程中的作用以及抑制异位钙化的能力迄今为止已经获得了最大的进展。胎球蛋白-A 在肿瘤进展中的潜在作用源于早期的研究，这些研究表明它是血清中的细胞附着因子。胎球蛋白-A 具有作为肝功能障碍、心血管疾病和代谢综合征相关疾病的生物标志物的诊断潜力^[1][2]。

Mouse

HEK293

C-10*His

P29699 (A19-I345)

11625  [NCBI]

APQGTGLGFRELACDDPEAEQVALLAVDYLNNHLLQGFKQVLNQIDKVKVWSRRPFGVVYEMEVDTLETTCHALDPTPLANCSVRQLTEHAVEGDCDFHILKQDGQFRVMHTQCHSTPDSAEDVRKLCPRCPLLTPFNDTNVVHTVNTALAAFNTQNNGTYFKLVEISRAQNVPLPVSTLVEFVIAATDCTAKEVTDPAKCNLLAEKQHGFCKANLMHNLGGEEVSVACKLFQTQPQPANANAVGPVPTANAALPADPPASVVVGPVVVPRGLSDHRTYHDLRHAFSPVASVESASGETLHSPKVGQPGAAGPVSPMCPGRIRHFKI

45-71 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 7.5 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.

• [1]. Anna Maria Dabrowska, et al. Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Sep;159(3):352-9.  [Content Brief]

  [2]. Josiah Ochieng, et al. Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes. Int J Mol Sci. 2018 Jul 29;19(8):2211.  [Content Brief]