1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Angiopoietins
  4. ANG-2
  5. Angiopoietin-2 蛋白, Cynomolgus/Rhesus Macaque (495a.a, HEK293, His)

Angiopoietin-2 蛋白, Cynomolgus/Rhesus Macaque (495a.a, HEK293, His)

目录号: HY-P76149
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Angiopoietin-2 (Ang2) 是属于血管生成素/Tie (具有 Ig 和 EGF 同源结构域的酪氨酸激酶)信号通路的生长因子,是参与血管生成的主要通路之一。Ang2 是一种 496 个氨基酸长的蛋白质,具有分泌信号肽、NH2 末端卷曲螺旋结构域和 COOH 末端纤维蛋白原样结构域。Ang2主要抑制Ang1诱导的Tie2磷酸化。Ang2对于内皮细胞生理学至关重要,并通过调节内皮通透性和血管生成功能在血管相关疾病中发挥核心作用。Angiopoietin-2 蛋白, Cynomolgus/Rhesus Macaque (495a.a, HEK293, His) 是重组的 血管生成素 2 蛋白,由 HEK293 表达,带有 C-His 标签。Angiopoietin-2 蛋白, Cynomolgus/Rhesus Macaque (495a.a, HEK293, His) 全长 495 个氨基酸,分子量约为 ~56.2 KDa。

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描述

Angiopoietin-2 (Ang2) is a growth factor that belongs to the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway, which is one of the main pathways involved in angiogenesis. Ang2 is a 496 amino acid long protein with a secretory signal peptide, an NH2-terminal coiled-coil domain, and a COOH-terminal fibrinogen-like domain. Ang2 mainly inhibits Ang1-induced Tie2 phosphorylation. Ang2 is critical for endothelial cell physiology and plays a central role in vascular-related diseases by regulating endothelial permeability and angiogenic functions. Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (495a.a, HEK293, His) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (495a.a, HEK293, His) is 495 a.a., with molecular weight of ~56.2 KDa.

研究背景

Ang2 是一种长 496 个氨基酸的蛋白质,与 Ang1 具有约 60% 的氨基酸同源性,并且缺乏成熟 Ang1 中发现的九个半胱氨酸之一。它具有分泌信号肽、NH2 末端卷曲螺旋结构域和 COOH 末端纤维蛋白原样结构域。与 Ang1 不同,Ang2 以自分泌方式发挥作用,其表达受到高度调控。与Ang1类似,Ang2以相同的结合亲和力与Tie2受体结合,诱导其拮抗作用,但不与Tie1结合。Ang2 表达由凝血酶等炎症介质和缺氧和癌症等条件触发[1]
ANGPT2 被描述为一种背景依赖性拮抗剂,干扰血管生成素-1 诱导的 Tie2 磷酸化,从而破坏血管稳定性并促进血管生成,可能会导致对抗血管生成治疗产生耐药性。ANGPT2被发现在多种肿瘤细胞中高表达,在肿瘤血管生成和炎症中发挥重要作用[2]

种属

Rhesus Macaque

表达系统

HEK293

标签

C-His

蛋白编号

XP_005562586 (M1-F495)

基因 ID

101925495  [NCBI]

蛋白结构
N-term
Angiopoietin-2 (M1-F495)
Accession # XP_005562586
His
C-term
同用名
Angiopoietin-2; ANG-2; ANGPT2
分子量

Approximately 56.2 kDa.

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (495a.a, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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