APRIL/TNFSF13 Trimer 蛋白, Human (Biotinylated, HEK293, Flag, His-Avi)

APRIL/TNFSF13 is a TNF superfamily cytokine that affects tumor cell growth by binding to TNFRSF13B/TACI and TNFRSF17/BCMA receptors. Its homotrimeric structure highlights a potential role in oncogenic processes and immune functions involving monocytes and macrophages. APRIL/TNFSF13 Trimer Protein, Human (Biotinylated, HEK293, Flag, His-Avi) is the recombinant human-derived APRIL/TNFSF13 protein, expressed by HEK293 , with N-Flag, C-Avi, N-His labeled tag.

APRIL/TNFSF13 是肿瘤坏死因子 (TNF) 超家族的细胞因子，通过与 TNFRSF13B/TACI 和 TNFRSF17/BCMA 受体结合发挥其生物学作用。作为同源三聚体，APRIL/TNFSF13 参与肿瘤细胞生长的调节，突出了其在致癌过程中的潜在重要性。此外，APRIL/TNFSF13 可能在单核细胞和巨噬细胞介导的免疫过程中发挥作用。通过与特定受体的相互作用，APRIL/TNFSF13 有助于形成控制细胞行为和免疫反应的复杂调节网络。阐明 APRIL/TNFSF13 的多方面功能为其在健康和疾病中的作用提供了宝贵的见解，特别是在肿瘤生物学和免疫系统调节的背景下。

Immobilized Human BCMA, hFc Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human APRIL (Trimer) , His Tag with the EC₅₀ of 16.3ng/ml determined by ELISA.

Human

HEK293

N-Avi;N-8*His;N-Flag

O75888-1 (K112-L250)

8741  [NCBI]

Partial

Approximately 55-65 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of 20mM PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.