ARL2BP 蛋白, Human (His)

The ARL2BP protein cooperates with ARL2 to play a crucial role in the nuclear translocation, retention, and transcriptional activity of STAT3, highlighting its cellular involvement. As a potential effector of ARL2, ARL2BP forms a complex with ARL2, SLC25A6, and ARL3. ARL2BP Protein, Human (His) is the recombinant human-derived ARL2BP protein, expressed by E. coli , with N-6*His labeled tag. The total length of ARL2BP Protein, Human (His) is 163 a.a., with molecular weight of ~21 KDa.

ARL2BP 蛋白与 ARL2 合作，在 STAT3 的核转位、保留和转录活性中发挥着关键作用，突出了它在细胞过程中的参与。ARL2BP 存在于与 ARL2 和 SLC25A6 以及 ARL2、ARL2BP 和 SLC25A4 的复合物中，可能作为 ARL2 的效应子。它与关键转录因子（包括 STAT2、STAT3 和 STAT4）相互作用，并且在 ARL2 存在的情况下与 STAT3 的相互作用增强。值得注意的是，ARL2BP 与 GTP 结合的 ARL2 和 ARL3 的关联，无论是作为 ARL2-ARL2BP 复合物还是单独的 ARL2BP，都与 SLC25A4 结合，表明在蛋白质靶向中发挥作用。此外，与 ARL2 的相互作用对于 ARL2BP 特异性靶向纤毛基体可能至关重要。这些错综复杂的关联强调了 ARL2BP 在细胞信号传导和定位过程中的多方面参与。

Data is not available.

Human

E. coli

N-6*His

Q9Y2Y0 (M1-H163)

23568  [NCBI]

MDALEGESFALSFSSASDAEFDAVVGYLEDIIMDDEFQLLQRNFMDKYYLEFEDTEENKLIYTPIFNEYISLVEKYIEEQLLQRIPEFNMAAFTTTLQHHKDEVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEGRGLDLSSGLVVTSLCKSSSLPASQNNLRH

Approximately 21 kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.