1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Stimulatory Immune Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins
  4. B7-H2/ICOSLG B7-H2/CD275
  5. B7-H2/ICOSLG 蛋白, Mouse (HEK293, His-Fc)

B7-H2/ICOSLG 蛋白, Mouse (HEK293, His-Fc)

目录号: HY-P73119
产品使用指南

B7-H2/ICOSLG 是 T 细胞受体 ICOS 的重要配体,介导免疫反应。它作为共刺激信号,促进 T 细胞和 B 细胞增殖、细胞因子分泌和浆细胞分化。B7-H2/ICOSLG 蛋白, Mouse (HEK293, His-Fc) 是重组的 B7-H2/ICOSLG 蛋白,由 HEK293 表达,带有 C-hFc, C-His 标签。B7-H2/ICOSLG 蛋白, Mouse (HEK293, His-Fc) 全长 233 个氨基酸,分子量为 75-85 kDa。

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描述

B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses. It acts as a costimulatory signal, promoting T and B cell proliferation, cytokine secretion, and plasma cell differentiation. B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc) is 233 a.a., with molecular weight of 75-85 kDa.

研究背景

B7-H2/ICOSLG 是 T 细胞特异性表面受体 ICOS 的配体,是免疫反应的重要介质。该蛋白充当共刺激信号,促进 T 细胞增殖和细胞因子分泌,同时诱导 B 细胞增殖和分化为浆细胞。除了在免疫激活中的作用之外,B7-H2/ICOSLG 可能在炎症条件下介导局部组织反应中发挥关键作用。此外,它还通过共同刺激记忆 T 细胞功能来调节二次免疫反应。值得注意的是,在怀孕期间,B7-H2/ICOSLG 可能会影响母体 T 细胞的细胞因子谱,有利于免疫保护性 Th2 表型。此外,在体外观察到了 B7-H2/ICOSLG 与 CTLA4 的相互作用,突显了其参与复杂的免疫功能调节途径。

种属

Mouse

表达系统

HEK293

标签

C-hFc;C-His

蛋白编号

Q9JHJ8 (E47-K279)

基因 ID

50723  [NCBI]

蛋白结构
N-term
B7-H2 (E47-K279)
Accession # Q9JHJ8
hFc-His
C-term
同用名
ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275
分子量

75-85 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc)
目录号:
HY-P73119
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