C1QTNF3/CTRP3 蛋白, Human (His)

C1QTNF3/CTRP3 Protein is a secreted protein of the C1q/ TNF-associated protein (CTRPs) family. C1QTNF3/CTRP3 Protein by participating in the TGF-尾1/Smad, Sirtuin 1/NF-魏B, AMPK and Signaling pathways such as LAMP1/JIP2/JNK have extensive effects on tumor, inflammation, metabolism, and insulin sensitization. C1QTNF3/CTRP3 Protein, Human (His) is the recombinant human-derived C1QTNF3/CTRP3 protein, expressed by E. coli , with N-His labeled tag. The total length of C1QTNF3/CTRP3 Protein, Human (His) is 224 a.a., with molecular weight of ~28.2 kDa.

C1q/ TNF 相关蛋白 (CTRPs) 是一类具有特定结构的分泌蛋白家族。CTRPs 对生存信号、炎症、代谢和胰岛素增敏有广泛影响。Complement C1q tumor necrosis factor-related protein 3 通过调节 TGF-β1/Smad 信号通路，抑制瘢痕疙瘩成纤维细胞 KFs 的增殖、迁移和 ECM 积累，发挥抗纤维化作用。C1QTNF3 参与多囊卵巢综合征 (PCOS) 的发病机制和胰岛素抵抗。C1QTNF3 通过 Sirtuin 1/NF-κB 信号通路减轻肠道炎症。C1QTNF3 通过 AMPK 信号通路影响肾小管细胞的脂质代谢和坏死炎症。C1QTNF3 通过激活 LAMP1/JIP2/JNK 通路减轻小鼠心肌缺血/再灌注损伤。

Human

E. coli

N-His

Q9BXJ4 (23Q-246K)

114899  [NCBI]

QDEYMESPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

Approximately 28.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in Tris-based buffer, 50% glycerol.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.