2. 重组蛋白
  3. Complement System
  4. Complement Component 2
  5. C2/Complement C2 蛋白, Mouse (HEK293, His)

C2/Complement C2 蛋白, Mouse (HEK293, His)

目录号: HY-P74374
产品使用指南

补体 C2 是补体系统经典途径的一个组成部分，被激活的因子 C1 裂解，导致形成两个不同的片段：C2b 和 C2a。C2a 随后的丝氨酸蛋白酶活性对于其随后与补体因子 C4b 的相互作用至关重要，从而导致 C3 或 C5 转化酶的形成。C2/Complement C2 蛋白, Mouse (HEK293, His) 是重组的 C2/补体 C2 蛋白，由 HEK293 表达，带有 C-His 标签。C2/Complement C2 蛋白, Mouse (HEK293, His) 全长 760 个氨基酸，分子量约为 ~91.2 kDa。

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描述

Complement C2 is a component of the classical pathway of the complement system and is cleaved by activated factor C1, resulting in the formation of two distinct fragments: C2b and C2a. The subsequent serine protease activity of C2a is critical for its subsequent interaction with the complement factor C4b, leading to the formation of C3 or C5 convertase. C2/Complement C2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived C2/Complement C2 protein, expressed by HEK293 , with C-His labeled tag. The total length of C2/Complement C2 Protein, Mouse (HEK293, His) is 760 a.a., with molecular weight of ~91.2 kDa.
研究背景

补体 C2 是补体系统内经典途径的重要组成部分，被激活的因子 C1 裂解成两个片段：C2b 和 C2a。生成的 C2a 片段具有丝氨酸蛋白酶活性，随后与补体因子 C4b 结合，最终形成 C3 或 C5 转化酶。这种酶复合物在补体系统的激活级联中发挥着关键作用，促进补体因子 C3 和 C5 的下游蛋白水解裂解，这是免疫反应中不可或缺的步骤。C2 在经典途径中精心策划的相互作用强调了其在介导免疫防御机制和维持免疫稳态方面的重要性。（参考：提供的资料）
种属

Mouse
表达系统

HEK293
标签

C-His
蛋白编号

P21180 (M1-L760)
基因 ID

12263  [NCBI]
蛋白结构
N-term
C2 (M1-L760)
Accession # P21180
His
C-term
同用名
Complement C2; C3/C5 convertase; C2
分子量

Approximately 91.2 kDa
纯度

Greater than 85% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

C2/Complement C2 Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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