CALCB 蛋白, Human (93a.a, HEK293, Fc)

CALCB Protein, Human (93a.a, HEK293, Fc), a recombinant human Calcitonin Gene-related Peptide 2 produced in HEK293 cells, has an Fc fragment at the C-terminus. Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, is a highly potent vasodilator^[1].

降钙素基因相关肽（CGRP）有两种主要形式（α 和 β）。它属于一组作用于不寻常受体家族的肽。这些受体由降钙素受体样受体 (CLR) 组成，该受体与必需受体活性修饰蛋白 (RAMP) 连接，这是完整功能所必需的。CGRP 是一种高效的血管扩张剂，因此具有对涉及心血管系统和伤口愈合的生理和病理状况非常重要的保护机制^[1]。

Human

HEK293

C-Fc

P10092 (A26-F118)

797  [NCBI]

APFRSALESSPDPATLSKEDARLLLAALVQDYVQMKASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAF-Fctag

38-42 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. F A Russell, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142.  [Content Brief]