2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. CCL27
  7. CCL27 蛋白, Human (N-His)

CCL27 蛋白, Human (N-His)

目录号: HY-P7767A
产品使用指南

CCL27 蛋白选择性地吸引皮肤相关记忆 T 淋巴细胞，通过 CCR10 结合介导它们归巢至皮肤部位。CCL27 对于皮肤免疫调节至关重要，以单体、二聚体和四聚体形式存在，肝素促进其寡聚化。与 TNFAIP6 的相互作用，特别是通过其 Link 结构域，意味着在皮肤微环境内的皮肤免疫反应和炎症中发挥调节作用。CCL27 蛋白, Human (N-His) 是重组的 CCL27 蛋白，由 E. coli 表达，带有 N-His 标签。CCL27 蛋白, Human (N-His) 全长 88 个氨基酸，分子量约为 ~14 kDa。

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描述

CCL27 protein selectively attracts skin-associated memory T-lymphocytes, mediating their homing to cutaneous sites through CCR10 binding. Crucial for skin immunity regulation, CCL27 exists as a monomer, dimer, and tetramer, with heparin promoting its oligomerization. Interaction with TNFAIP6, particularly through its Link domain, implies regulatory roles in skin immune responses and inflammation within the skin microenvironment. CCL27 Protein, Human (N-His) is the recombinant human-derived CCL27 protein, expressed by E. coli , with N-His labeled tag. The total length of CCL27 Protein, Human (N-His) is 88 a.a., with molecular weight of ~14 kDa.
研究背景

CCL27 蛋白作为一种趋化因子，专门吸引皮肤相关的记忆 T 淋巴细胞，并参与介导淋巴细胞归巢至皮肤部位。通过与 CCR10 结合，CCL27 协调皮肤中免疫细胞的迁移，表明其在皮肤免疫调节中的关键作用。该蛋白质以单体、二聚体和四聚体形式存在，肝素极力促进其寡聚化。此外，CCL27 与 TNFAIP6 相互作用，特别是通过其 Link 结构域，表明在皮肤微环境内的免疫反应和炎症过程中具有潜在的调节作用。
种属

Human
表达系统

E. coli
标签

N-His
蛋白编号

Q9Y4X3 (F25-G112)
基因 ID
蛋白结构
N-term
His
CCL27 (F25-G112)
Accession # Q9Y4X3
C-term
中文名
重组人C-C基序趋化因子27
同用名
rHuCCL27; C-C Motif Chemokine 27; CC Chemokine ILC; Cutaneous T-Cell-Attracting Chemokine; CTACK; Eskine; IL-11 R-Alpha-Locus Chemokine; Skinkine; Small-Inducible Cytokine A27; CCL27; ILC; SCYA27
分子量

Approximately 14 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CCL27 Protein, Human (N-His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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