CCL27 - C-C motif chemokine ligand 27 Gene

中文名称：CC 基序趋化因子配体 27

种属: Homo sapiens

同用名: ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27

基因 ID: 10850 | 基因类型: protein coding

关于 CCL27

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,661,890-34,662,657 (from NCBI)

This gene has 2 transcripts (splice variants), 106 orthologues and 1 paralogue. Biased expression in skin (RPKM 77.8), spleen (RPKM 8.8) and 11 other tissues.

功能概要

该基因是聚集在 9 号染色体 p 臂上的几个 CC 细胞因子基因之一。细胞因子是一个参与免疫调节和炎症过程的分泌蛋白家族。 CC 细胞因子是以两个相邻的半胱氨酸为特征的蛋白质。由该基因编码的蛋白质对皮肤相关记忆 T 淋巴细胞具有趋化性。这种细胞因子也可能在介导淋巴细胞归巢至皮肤部位方面发挥作用。它特异性结合趋化因子受体 10 (CCR10) 。对类似鼠类蛋白质的研究表明，这些蛋白质-受体相互作用在 T 细胞介导的皮肤炎症中起着关键作用。[RefSeq 提供，2014 年 9 月]

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to Chemokine Receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

CCL27 基因产物(1)

mRNA	Protein	Name
NM_006664.4	NP_006655.1	C-C motif chemokine 27 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables CCR3 chemokine receptor binding	IPI IPI: 通过物理相互作用推断	12538707	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28381538	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	19109182	GOA
involved in killing of cells of another organism	IDA IDA: 通过直接分析推断	19109182	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCL27 蛋白结构

IL8

0
100
112 a.a.

蛋白主名

其他名称

C-C motif chemokine 27

CC chemokine ILC

CCL27 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCL27	Q9Y4X3	CCL5	Homo sapiens	P13501	Filter Binding	28381538

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CCL27 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7767	CTACK/CCL27 Protein, Human	Q9Y4X3 (F25-G112)	≥95%
HY-P7767A	CTACK/CCL27 Protein, Human (His)	Q9Y4X3 (F25-G112)	≥95%

CCL27 抗体

目录号	产品名	应用	反应物种
HY-P84895	CCL27 Antibody (YA4592)	IHC-P, ICC/IF, FC, ELISA	Human

关联疾病

疾病名称

别名

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Allergic Contact Dermatitis

Dermatitis, Allergic Contact	Contact Dermatitis, Allergic
Dermatitis Allergic Contact	Allergic Contact Eczema
Acd - [Allergic Contact Dermatitis]	Allergic Contact Dermatitis, Unspecified Cause
Allergic Dermatitis	Allergic Eczema
Allergy Dermatitis	Allergy Eczema
Allergic Contact Eczema Due To Clothing Or Footwear	Perfume Allergic Contact Dermatitis
Allergic Contact Dermatitis Due To Cosmetics	Allergic Contact Eczema Due To Cosmetics Or Fragrances
Allergic Contact Eczema Due To Dental Materials	Allergic Contact Eczema Due To Food Flavours Or Additives
Allergic Contact Eczema Due To Hairdressing Products	Allergic Contact Eczema Due To Metals Or Metal Salts
Allergic Contact Eczema Due To Proteins	Allergic Contact Eczema Due To Plastics Or Resin Systems
Allergic Contact Eczema Due To Preservatives Or Biocides	Allergic Contact Eczema Due To Rubber Chemicals
Rubber Dermatitis	Allergic Contact Eczema Due To Systemic Medicaments
Allergic Contact Eczema Due To Topical Medicaments	Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Hypophosphatasia

Phosphoethanolaminuria	Childhood Hypophosphatasia
Deficiency Of Alkaline Phosphatase	Hypophospatasia, Childhood
Hypophosphatasia Mild	Phosphoethanol-Aminuria
Rathburn Disease	Hpp
Rathbun Disease	Hypophosphatasia, Childhood
Infantile Hypophosphatasia

Chancroid

Ulcus Molle, Skin	Chancroids
Bubo Due To Haemophilus Ducreyi	Soft Chancre
Ulcus Molle

Psoriasis

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Irritant Dermatitis

Irritant Contact Dermatitis	Primary Irritant Dermatitis
Dermatitis, Irritant	Contact Dermatitis, Irritant
Irritant Contact Eczema	Icd - [Irritant Contact Dermatitis]
Irritant Contact Dermatitis, Unspecified Cause	Non-Allergic Contact Dermatitis
Irritant Contact Eczema Due To Wet Work	Irritant Contact Dermatitis Due To Detergents
Irritant Contact Eczema Due To Solvents	Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants
Irritant Contact Eczema Due To Cosmetics Or Emollients	Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials
Irritant Contact Eczema Due To Plants Or Other Vegetable Matter	Irritant Contact Eczema Due To Foods
Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids	Irritant Contact Eczema Due To Saliva
Irritant Contact Eczema Due To Incontinence	Incontinence-Associated Dermatitis

Norwegian Scabies

Crusted Scabies

Seven Year Itch

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02097	CCL27 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25136	Ccl27 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CCL27	VGNC	VGNC:102906
Canis familiaris	CCL27	VGNC	VGNC:38889
Rattus norvegicus	CCL27	RGD	RGD:1304660
Macaca mulatta	CCL27	VGNC	VGNC:103246
Bos taurus	CCL27	VGNC	VGNC:26952
Mus musculus	CCL27	NCBI
Others	CCL27	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCL27 - C-C motif chemokine ligand 27 Gene

关于 CCL27

功能概要

CCL27 基因产物(1)

CCL27 蛋白结构

CCL27 蛋白互作信息

重组 CCL27 蛋白

CCL27 抗体

关联疾病

直系同源

热门区域

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CCL27 - C-C motif chemokine ligand 27 Gene

关于 CCL27

功能概要

CCL27 基因产物(1)

CCL27 蛋白结构

CCL27 蛋白互作信息

重组 CCL27 蛋白

CCL27 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z