CCR5 Protein-VLP, Human (HEK293)

CCR5 Protein, a receptor for inflammatory CC-chemokines like CCL3/MIP-1-alpha, CCL4/MIP-1-beta, and RANTES, transduces signals, elevating intracellular calcium levels. It regulates granulocytic lineage and facilitates T-lymphocyte migration to infection sites. In microbial infection, CCR5 acts as a coreceptor, along with CD4, for HIV-1, emphasizing its role in the cellular response to infections. CCR5 Protein-VLP, Human (HEK293) is the recombinant human-derived CCR5 protein, expressed by HEK293, with tag free.Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening. Given the high immunogenicity of VLPs, the immunization protocol such as antigen dose, schedule, and adjuvant, requires optimization. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

CCR5 作为多种炎症性 CC 趋化因子（包括 CCL3/MIP-1-alpha、CCL4/MIP-1-beta 和 RANTES）的受体发挥作用，导致信号转导，从而提高细胞内钙离子水平。该受体参与粒细胞谱系增殖或分化的调节，并作为趋化受体在促进 T 淋巴细胞迁移至感染部位方面发挥着至关重要的作用。在微生物感染的情况下，CCR5 充当人类免疫缺陷病毒-1/HIV-1 的辅助受体，CD4 是主要受体，强调了其在细胞对感染反应中的重要性。

Human

HEK293

Tag Free

P51681 (M1-L352)

1234

Full Length

溶液.

Supplied as 0.2 μm filtered solution of PBS, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.