2. 重组蛋白
  3. CD Antigens
  4. T Cell CD Proteins Dendritic Cell CD Proteins
  5. CD1c
  6. CD1C-B2M Heterodimer 蛋白, Rhesus Macaque (HEK293, His)

CD1C-B2M Heterodimer 蛋白, Rhesus Macaque (HEK293, His)

目录号: HY-P76210
产品使用指南

CD1C 属于跨膜糖蛋白 CD1 家族的第 1 族。CD1C 蛋白作为一个关键的抗原呈递分子，显示出结合自身和非自身脂质和糖脂抗原的能力，介导宿主防御结核病。CD1C 与乳腺癌预后和免疫浸润相关。CD1C-B2M Heterodimer 蛋白, Rhesus Macaque (HEK293, His) 是重组的蛋白二聚体复合物，包含 CD1C-B2M 异二聚体蛋白，由 HEK293 表达，带有 C-His 标签。CD1C-B2M Heterodimer 蛋白, Rhesus Macaque (HEK293, His) ，分子量约为 ~44.7 (33.1+ 11.6) KDa。

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描述

CD1C belongs to Group 1 of the transmembrane glycoprotein CD1 family. CD1C protein, as a key antigen-presenting molecule, has shown the ability to bind both self and non-self lipid and glycolipid antigens, mediating host defense against tuberculosis. CD1C is associated with breast cancer prognosis and immune invasion. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD1C-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His), has molecular weight of ~44.7 (33.1+ 11.6) KDa.
研究背景

CD1C 属于跨膜糖蛋白 CD1 家族的第 1 族。CD1 分子在许多不同的人类抗原呈递细胞 (DC、单核胞和某些胸腺细胞) 表面表达。CD1C 蛋白作为一个关键的抗原呈递分子，显示出结合自身和非自身脂质和糖脂抗原的能力，从而促进它们在自然杀伤 T 细胞上向 T 细胞受体呈递。人类 1 组 CD1 分子 (CD1a, CD1b 和 CD1c ) 结合由分枝杆菌表达的脂质抗原池并将其呈递给特异性 T 细胞，从而介导宿主防御结核病的有效途径。CD1C 与乳腺癌预后和免疫浸润相关。
种属

Rhesus Macaque
表达系统

HEK293
标签

C-His
蛋白编号

NP_001139005 (Q21-F298)& NP_001040602 (I21-M119)
基因 ID

717148  [NCBI]&712428  [NCBI]
同用名
T-cell surface glycoprotein CD1c; CD1C; Beta-2-microglobulin; B2M
分子量

Approximately 44.7 (33.1+ 11.6) kDa.
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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