1. 重组蛋白
  2. CAR-T related Proteins CD Antigens Biotinylated Proteins
  3. B Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins
  4. CD20
  5. CD20/MS4A1 蛋白, Human (His-Avi)

CD20/MS4A1 蛋白, Human (His-Avi)

目录号: HY-P78086
产品使用指南

CD20/MS4A1蛋白是一种B淋巴细胞膜蛋白,在细胞钙内流中起着至关重要的调节作用,这对于B淋巴细胞的发育、分化和激活至关重要。作为钙库操纵 (SOC) 通道的一部分,它在 B 细胞受体/BCR 激活时促进钙流入。CD20/MS4A1 蛋白, Human (His-Avi) 是重组的 CD20/MS4A1 蛋白,由 E. coli 表达,带有 C-Avi, C-His 标签。CD20/MS4A1 蛋白, Human (His-Avi) 全长 48 个氨基酸,分子量约为 ~16.8 kDa。

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描述

CD20/MS4A1 protein is a B lymphocyte membrane protein that plays a crucial regulatory role in cellular calcium influx, which is essential for the development, differentiation and activation of B lymphocytes. As part of a store-operated calcium (SOC) channel, it promotes calcium influx upon B cell receptor/BCR activation. CD20/MS4A1 Protein, Human (His-Avi) is the recombinant human-derived CD20/MS4A1 protein, expressed by E. coli , with C-Avi, C-His labeled tag. The total length of CD20/MS4A1 Protein, Human (His-Avi) is 48 a.a., with molecular weight of ~16.8 kDa.

研究背景

CD20/MS4A1 蛋白是一种 B 淋巴细胞特异性膜蛋白,在调节细胞钙内流方面发挥着至关重要的作用,而钙内流对于 B 淋巴细胞的发育、分化和激活至关重要。它作为钙库操纵 (SOC) 通道的组成部分发挥作用,在 B 细胞受体/BCR 激活后促进钙流入。CD20/MS4A1 形成同源四聚体,有助于其结构组织和在钙信号传导中的功能作用。值得注意的是,它与细胞表面 IgM 的重链和轻链(BCR 的抗原结合成分)相互作用,突出了它在 B 细胞受体复合物中的参与,并强调了它在 B 细胞激活和免疫反应中的重要性。

种属

Human

表达系统

E. coli

标签

C-Avi;C-His

蛋白编号

P11836 (I141-S188)

基因 ID

931  [NCBI]

蛋白结构
N-term
CD20 (I141-S188)
Accession # P11836
His-Avi
C-term
同用名
MS4A1; CD20; MS4A-1; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 11
分子量

Approximately 16.8 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD20/MS4A1 Protein, Human (His-Avi)
目录号:
HY-P78086
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