1. 重组蛋白
  2. CD Antigens
  3. B Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion-related CD Proteins
  4. CD44/ECMR-III
  5. CD44 蛋白, Human (220a.a, HEK293, Fc)

CD44 蛋白, Human (220a.a, HEK293, Fc)

目录号: HY-P74293
产品使用指南

CD44 是一种细胞表面受体,在钙动员和肌动蛋白介导的细胞骨架重组、细胞迁移和粘附中发挥关键作用。CD44 蛋白, Human (220a.a, HEK293, Fc) 是重组的 CD44 蛋白,由 HEK293 表达,带有 C-hFc 标签。CD44 蛋白, Human (220a.a, HEK293, Fc) 全长 200 个氨基酸,分子量约为 ~76 kDa。

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重组蛋白定制服务

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     可免费申领三个不同产品的试用装。

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描述

CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (220a.a, HEK293, Fc) is the recombinant human-derived CD44 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD44 Protein, Human (220a.a, HEK293, Fc) is 200 a.a., with molecular weight of ~76 kDa.

研究背景

CD44 是一种细胞表面受体,在细胞间相互作用、粘附和迁移中发挥着关键作用,使细胞能够感知并响应组织微环境的变化。它涉及多种细胞功能,包括 T 淋巴细胞的激活、再循环和归巢、造血、炎症和对细菌感染的反应。CD44 通过其胞外域结合各种细胞外基质成分,如乙酰透明质酸/HA、胶原蛋白、生长因子、细胞因子或蛋白酶,作为信号转导的平台。这涉及通过其细胞质结构域组装蛋白质复合物,其中包含受体激酶和膜蛋白酶。PKN2、RAC1、RHOA、Rho 激酶和磷脂酶 C 等效应器与 CD44 协调信号传导通路,导致钙动员和肌动蛋白介导的细胞骨架重组,这对细胞迁移和粘附至关重要。CD44 与一系列分子相互作用,包括 PKN2、TIAM1、TIAM2、透明质酸、胶原蛋白、层粘连蛋白、纤连蛋白、UNC119、PDPN、RDX、EZR、MSN、EGFR 和 CD74,形成对其多种细胞功能至关重要的复杂网络。

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

P16070 (Q21-P220)

基因 ID

960  [NCBI]

蛋白结构
N-term
CD44 (Q21-P220)
Accession # P16070
hFc
C-term
同用名
CD44 antigen; CDw44; Epican; ECMR-III; CD44; LHR; MDU2
分子量

Approximately 76 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD44 Protein, Human (220a.a, HEK293, Fc)
目录号:
HY-P74293
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