CDTB 蛋白, E.coli (Myc, His-SUMO)

CDTB Protein, integral to the tripartite complex for Cytolethal Distending Toxin (CDT) activity, features DNA-nicking endonuclease action, likely causing DNA damage. This damage prompts G2/M cell cycle arrest, chromatin fragmentation, cell distention, and nucleus enlargement. Collaborating with CdtA and CdtC, CDTB forms a crucial unit for CDT's cytotoxic effects, showcasing its multifaceted role in cellular responses to CDT intoxication. CDTB Protein, E.coli (Myc, His-SUMO) is the recombinant E. coli-derived CDTB protein, expressed by E. coli , with N-His, C-Myc, N-SUMO labeled tag. The total length of CDTB Protein, E.coli (Myc, His-SUMO) is 251 a.a., with molecular weight of ~47.4 kDa.

CDTB 蛋白是细胞致死膨胀毒素 (CDT) 活性所必需的三方复合物的组成部分。凭借其独特的 DNA 切口核酸内切酶活性，CdtB 可能会诱导靶细胞中的 DNA 损伤。这种损伤反过来会引发 G2/M 细胞周期停滞、染色质断裂、细胞膨胀和细胞核增大。CDTB 在异源三聚体组装中与 CdtA 和 CdtC 一起发挥作用，形成对 CDT 的细胞毒性作用至关重要的内聚单元。这些亚基错综复杂的相互作用强调了 CDTB 在细胞对 CDT 中毒反应中的多方面作用。

E.coli

E. coli

N-His;C-Myc;N-SUMO

Q46669 (19D-269R)

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DLTDFRVATWNLQGASATTESKWNINVRQLISGENAVDILAVQEAGSPPSTAVDTGTLIPSPGIPVRELIWNLSTNSRPQQVYIYFSAVDALGGRVNLALVSNRRADEVFVLSPVRQGGRPLLGIRIGNDAFFTAHAIAMRNNDAPALVEEVYNFFRDSRDPVHQALNWMILGDFNREPADLEMNLTVPVRRASEIISPAAATQTSQRTLDYAVAGNSVAFRPSPLQAGIVYGARRTQISSDHFPVGVSRR

Approximately 47.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.