1. 重组蛋白
  2. CD Antigens Receptor Proteins
  3. Stem Cell CD Proteins Epithelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. CD66d/CEACAM3 Immunoglobulin-like Cell Adhesion Molecules
  5. CEA Cell Adhesion Molecule 3 (CEACAM3)
  6. CEACAM3 蛋白, Human (HEK293, His)

CEACAM3 蛋白, Human (HEK293, His)

目录号: HY-P72694
产品使用指南

CEACAM3 蛋白是一种关键的粒细胞受体,可有效协调 CEACAM 结合微生物(如奈瑟氏菌属、莫拉氏菌属和嗜血杆菌属)的非调理素依赖性吞噬作用。这一作用使 CEACAM3 处于先天免疫系统中病原体清除的最前沿。CEACAM3 蛋白, Human (HEK293, His) 是重组的 CEACAM3 蛋白,由 HEK293 表达,带有 C-6*His 标签。CEACAM3 蛋白, Human (HEK293, His) 全长 121 个氨基酸,分子量为 18-20 kDa。

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描述

The CEACAM3 protein is a key granulocyte receptor that effectively orchestrates the opsonin-independent phagocytosis of CEACAM-bound microorganisms such as Neisseria spp., Moraxella spp., and Haemophilus spp. This role places CEACAM3 at the forefront of pathogen clearance in the innate immune system. CEACAM3 Protein, Human (HEK293, His) is the recombinant human-derived CEACAM3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CEACAM3 Protein, Human (HEK293, His) is 121 a.a., with molecular weight of 18-20 kDa.

研究背景

CEACAM3 蛋白是一种关键的粒细胞受体,可协调 CEACAM 结合微生物(包括奈瑟菌属、莫拉氏菌属和嗜血杆菌属等病原体)的高效非调理素依赖性吞噬作用。这一重要作用使 CEACAM3 处于先天免疫系统内病原体清除的最前沿。在病原体吞噬过程中,CEACAM3 负责刺激 RAC1,进一步促进病原体吞噬的细胞过程。值得注意的是,CEACAM3 与 S100A9/钙卫蛋白进行钙依赖性相互作用,这是一种独立于 CEACAM3 磷酸化而发生的动态相互作用。这种复杂的功能网络强调了 CEACAM3 在协调针对一系列微生物的有效免疫反应中的多方面作用。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

P40198 (K35-G155)

基因 ID
蛋白结构
N-term
CEACAM3 (K35-G155)
Accession # P40198
6*His
C-term
同用名
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3; CD66d; CEACAM3; CGM1
氨基酸序列

KLTIESMPLSVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNSLIVGYVIGTQQATPGAAYSGRETIYTNASLLIQNVTQNDIGFYTLQVIKSDLVNEEATGQFHVYQENAPGLPVGAVAG

分子量

18-20 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CEACAM3 Protein, Human (HEK293, His)
目录号:
HY-P72694
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