1. 重组蛋白
  2. Enzymes & Regulators
  3. Hydrolases (EC 3)
  4. CHD1L 蛋白, Human (His-SUMO)

CHD1L 蛋白, Human (His-SUMO)

目录号: HY-P71588
产品使用指南

CHD1L蛋白是线粒体钾通道的ATP结合亚基,与CCDC51/MITOK配合形成复合物,促进ATP依赖性钾电流穿过内膜(mitoK(ATP)通道)。ABCB8 对于线粒体铁转运至关重要,影响心脏功能,并调节胞质含铁硫酶的成熟。CHD1L 蛋白, Human (His-SUMO) 是重组的 CHD1L 蛋白,由 E. coli 表达,带有 N-His, N-SUMO 标签。CHD1L 蛋白, Human (His-SUMO) 全长 194 个氨基酸,分子量约为 ~37.3 kDa。

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描述

CHD1L protein is the ATP-binding subunit of the mitochondrial potassium channel and cooperates with CCDC51/MITOK to form a complex to promote ATP-dependent potassium current across the inner membrane (mitoK(ATP) channel). ABCB8 is essential for mitochondrial iron transport, affects cardiac function, and regulates the maturation of cytosolic iron-sulfur-containing enzymes. CHD1L Protein, Human (His-SUMO) is the recombinant human-derived CHD1L protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of CHD1L Protein, Human (His-SUMO) is 194 a.a., with molecular weight of ~37.3 kDa.

研究背景

ABCB8 是位于线粒体内膜的线粒体钾通道的 ATP 结合亚基。它与 CCDC51/MITOK 合作,形成位于线粒体内的蛋白质复合物,促进 ATP 依赖性钾电流穿过内膜,称为 mitoK(ATP) 通道。此外,ABCB8 在线粒体铁转运中发挥着至关重要的作用,对于维持正常心脏功能至关重要,可能影响线粒体铁输出并调节胞质含铁硫簇酶的成熟。值得注意的是,通道活性由 ATP 通过 ABCB8/MITOSUR 亚基调节。

种属

Human

表达系统

E. coli

标签

N-His;N-SUMO

蛋白编号

Q86WJ1 (704S-897P)

基因 ID
蛋白结构
N-term
6*His-SUMO
CHD1L (704S-897P)
Accession # Q86WJ1
C-term
同用名
ALC1; Amplified in liver cancer 1; Amplified in liver cancer protein 1; chd1l; CHD1L_HUMAN; CHDL; Chromodomain helicase DNA binding protein 1 like; Chromodomain-helicase-DNA-binding protein 1-like; FLJ22530
氨基酸序列

SAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGRGGLFTALEKRSAEPRKIYELAGKMKDLSLGGVLLFPVDDKESRNKGQDLLALIVAQHRDRSNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLIRKHLAARGIPTYIYYFPRSKSAVLHAQSSSSSSRQLVP

分子量

Approximately 37.3 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

CHD1L Protein, Human (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CHD1L Protein, Human (His-SUMO)
目录号:
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