Complement factor H/CFH 蛋白, Mouse (HEK293, Fc)

Complement factor H (CFH) protein has C3b and heparin-binding activity and plays a multifaceted role in various processes such as organ development, complement activation, and vasculature development. It is present in different cellular compartments and expressed in different structures, including the adrenal gland, bone, central nervous system, humeral cartilage condensation, and metanephros. Complement factor H/CFH Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Complement factor H/CFH protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Complement factor H/CFH Protein, Mouse (HEK293, Fc) is 378 a.a., with molecular weight of 80-94 kDa.

补体因子 H (CFH) 蛋白表现出多方面的作用，具有补体成分 C3b 结合活性和肝素结合活性。CFH 在各种生理过程（例如动物器官发育、补体激活和脉管系统发育）的上游发挥作用，存在于不同的细胞区室中，包括轴突、质膜外侧和神经元细胞体。它的表达跨越多个结构，包括肾上腺、骨骼、中枢神经系统、肱骨软骨凝结和后肾。这种蛋白质与多种疾病有关，例如非典型溶血性尿毒症综合征、眼病、狼疮性肾炎和系统性红斑狼疮，凸显了其在健康和疾病中的重要作用。该表达模式强调了其在组织中的重要存在，特别是在胚胎和成体阶段的肝脏中突出，强调了其在肝功能中的关键作用。

Measured in a cell proliferation assay using A549 cells. The ED₅₀ for this effect is 28.04 ng/mL, corresponding to a specific activity is 3.57×10^4 units/mg.

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  Measured in a cell proliferation assay using A549 cells. The ED₅₀ for this effect is 28.04 ng/mL, corresponding to a specific activity is 3.57×10⁴ units/mg.

Mouse

HEK293

C-hFc

NP_034018.2 (S875-V1252)

12628  [NCBI]

SLPRCIEKIPCSQPPTIEHGSINLPRSSEERRDSIESSSHEHGTTFSYVCDDGFRIPEENRITCYMGKWSTPPRCVGLPCGPPPSIPLGTVSLELESYQHGEEVTYHCSTGFGIDGPAFIICEGGKWSDPPKCIKTDCDVLPTVKNAIIRGKSKKSYRTGEQVTFRCQSPYQMNGSDTVTCVNSRWIGQPVCKDNSCVDPPHVPNATIVTRTKNKYLHGDRVRYECNKPLELFGQVEVMCENGIWTEKPKCRDSTGKCGPPPPIDNGDITSLSLPVYEPLSSVEYQCQKYYLLKGKKTITCRNGKWSEPPTCLHACVIPENIMESHNIILKWRHTEKIYSHSGEDIEFGCKYGYYKARDSPPFRTKCINGTINYPTCV

80-94 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4 (Normally trehalose is added as protectant before lyophilization. ) or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.