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Corneodesmosin/CDSN 蛋白, Human (HEK293, His)

目录号: HY-P7820
COA 产品使用指南

PSORS1C1/CDSN,是一种存在于角化桥粒中的角链蛋白,与人类表皮和其他角化鳞状上皮的修复有关。PSORS1C1/CDSN 的表达与银屑病等免疫皮肤病有关,Cdsn 缺陷则会出现皮肤屏障破损。Corneodesmosin/CDSN 蛋白, Human (HEK293, His) 是重组的 角链蛋白/CDSN 蛋白,由 HEK293 表达,带有 C-6*His 标签。Corneodesmosin/CDSN 蛋白, Human (HEK293, His) 全长 496 个氨基酸,分子量为 58-70 kDa。

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描述

PSORS1C1/CDSN, a keratin protein present in cornified desmosomes, is involved in the repair of human epidermis and other keratinized squamous epithelium. The expression of PSORS1C1/CDSN is associated with immune skin diseases such as psoriasis, and Cdsn deficiency causes skin barrier damage. Corneodesmosin/CDSN Protein, Human (HEK293, His) is the recombinant human-derived Corneodesmosin/CDSN protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Corneodesmosin/CDSN Protein, Human (HEK293, His) is 496 a.a., with molecular weight of 58-70 kDa.

研究背景

PSORS1C1/CDSN,是一种角化桥粒中发现的角链蛋白 (Corneodesmosin),角化桥粒定位于人类表皮和其他角化鳞状上皮。PSORS1C1/CDSN 由 CDSN 编码,主要导致银屑病(一种免疫皮肤病)的易感性。CDSN 在人群中具有多态性,且与强直性脊柱炎(AS)、牛皮癣、少毛症和脱皮综合征等有关。特别是脱皮性皮肤病,就是一种由常染色体隐性遗传的 CDSN 双等位基因突变引起的。在表皮特异性 Cdsn 缺陷小鼠模型中,则会出现表皮屏障破坏,表皮细胞因子的产生增加。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

AAH31993.1 (K33-P528)

基因 ID
蛋白结构
N-term
CDSN (K33-P528)
Accession # AAH31993.1
6*His
C-term
同用名
rHuCorneodesmosin/CDSN, His; Corneodesmosin; S Protein; CDSN
氨基酸序列

KSIGTFSDPCKDPTRITSPNDPCLTGKGDSSGFSSYSGSSSSGSSISSARSSGGGSSGSSSGSSIAQGGSAGSFKPGTGYSQVSYSSGSGSSLQGASGSSQLGSSSSHSGNSGSHSGSSSSHSSSSSSFQFSSSSFQVGNGSALPTNDNSYRGILNPSQPGQSSSSSQTSGVSSSGQSVSSNQRPCSSDIPDSPCSGGPIVSHSGPYIPSSHSVSGGQRPVVVVVDQHGSGAPGVVQGPPCSNGGLPGKPCPPITSVDKSYGGYEVVGGSSDSYLVPGMTYSKGKIYPVGYFTKENPVKGSPGVPSFAAGPPISEGKYFSSNPIIPSQSAASSAIAFQPVGTGGVQLCGGGSTGSKGPCSPSSSRVPSSSSISSSSGSPYHPCGSASQSPCSPPGTGSFSSSSSSQSSGKIILQPCGSKSSSSGHPCMSVSSLTLTGGPDGSPHPDPSAGAKPCGSSSAGKIPCRSIRDILAQVKPLGPQLADPEVFLPQGELLDSP

分子量

58-70 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

Corneodesmosin/CDSN Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Corneodesmosin/CDSN Protein, Human (HEK293, His)
目录号:
HY-P7820
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