2. 重组蛋白
  3. Receptor Proteins Enzymes & Regulators
  4. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. DDR Family
  6. DDR2
  7. DDR2 蛋白, Human (sf9, His-GST)

DDR2 蛋白, Human (sf9, His-GST)

目录号: HY-P76867
产品使用指南

DDR2 蛋白是一种在组织重塑中至关重要的酪氨酸激酶，作为纤维胶原的细胞表面受体，影响细胞分化、细胞外基质重塑、迁移和增殖。DDR2 对骨骼发育至关重要，并通过 MAP 激酶信号传导和 RUNX2 激活集中调节成骨细胞分化和软骨细胞成熟。DDR2 蛋白, Human (sf9, His-GST) 是重组的 DDR2 蛋白，由 Sf9 insect cells 表达，带有 N-His, N-GST 标签。DDR2 蛋白, Human (sf9, His-GST) 全长 434 个氨基酸，分子量约为 ~77 kDa。

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     可免费申领三个不同产品的试用装。

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描述

The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Human (sf9, His-GST) is the recombinant human-derived DDR2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of DDR2 Protein, Human (sf9, His-GST) is 434 a.a., with molecular weight of ~77 kDa.
研究背景

DDR2 蛋白是一种调节组织重塑不可或缺的酪氨酸激酶，可作为纤维胶原的细胞表面受体，控制细胞分化、细胞外基质重塑、细胞迁移和增殖。DDR2 对正常骨骼发育至关重要，通过涉及 MAP 激酶的信号通路在成骨细胞分化和软骨细胞成熟中发挥核心作用，最终激活转录因子 RUNX2。此外，DDR2通过上调胶原酶MMP1、MMP2和MMP13来调节细胞外基质重塑，从而促进细胞迁移和肿瘤细胞侵袭。它的参与延伸到促进成纤维细胞迁移和增殖，有助于皮肤伤口愈合的动态过程。
种属

Human
表达系统

Sf9 insect cells
标签

N-His;N-GST
蛋白编号

Q16832 (R422-E855)
基因 ID
蛋白结构
N-term
His-GST
DDR2 (R422-E855)
Accession # Q16832
C-term
同用名
Discoidin domain-containing receptor 2; CD167b; Ddr2; Ntrkr3; Tkt; Tyro10
分子量

Approximately 77 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

DDR2 Protein, Human (sf9, His-GST) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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