DDR2 蛋白, Rhesus Macaque (HEK293, His)

The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived DDR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DDR2 Protein, Rhesus Macaque (HEK293, His) is 399 a.a., with molecular weight of ~50-70 kDa.

DDR2 蛋白是一种调节组织重塑不可或缺的酪氨酸激酶，可作为纤维胶原的细胞表面受体，控制细胞分化、细胞外基质重塑、细胞迁移和增殖。DDR2 对正常骨骼发育至关重要，通过涉及 MAP 激酶的信号通路在成骨细胞分化和软骨细胞成熟中发挥核心作用，最终激活转录因子 RUNX2。此外，DDR2通过上调胶原酶MMP1、MMP2和MMP13来调节细胞外基质重塑，从而促进细胞迁移和肿瘤细胞侵袭。它的参与延伸到促进成纤维细胞迁移和增殖，有助于皮肤伤口愈合的动态过程。

Measured by its binding ability in a functional ELISA. Immobilized Collagen I at 10 µg/mL can bind Rhesus Macaque DDR2 with an apparent KD is 7.846 nM.

Rhesus Macaque

HEK293

C-6*His

XP_001118219.1 (M1-R399)

720124  [NCBI]

QVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMTPTTYDPMLKIDDSNTR

Approximately 50-70 kDa due to the glycosylation

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.