1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Ephrin/Eph Family
  4. Ephrins
  5. Ephrin-A3
  6. Ephrin-A3/EFNA3 蛋白, Mouse (HEK293, His)

Ephrin-A3/EFNA3 蛋白, Mouse (HEK293, His)

目录号: HY-P73009
COA 产品使用指南

Ephrin-A3/EFNA3 蛋白是一种 GPI 结合配体,与 Eph 受体相互作用,在神经元、血管和上皮发育中发挥关键作用。它结合相邻的 Eph 受体,启动双向信号传导。Ephrin-A3/EFNA3 还激活 EPHA8,有助于其迁移、排斥和粘附的调节功能。Ephrin-A3/EFNA3 蛋白, Mouse (HEK293, His) 是重组的 Ephrin-A3/EFNA3 蛋白,由 HEK293 表达,带有 C-His 标签。Ephrin-A3/EFNA3 蛋白, Mouse (HEK293, His) 全长 183 个氨基酸,分子量约为 ~38 kDa。

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2 μg ¥350 In-stock
10 μg ¥650 In-stock
50 μg ¥1800 In-stock
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描述

Ephrin-A3/EFNA3 Protein, a GPI-bound ligand, interacts with Eph receptors, playing a critical role in neuronal, vascular, and epithelial development. It binds adjacent Eph receptors, initiating bidirectional signaling. Ephrin-A3/EFNA3 also activates EPHA8, contributing to its regulatory functions in migration, repulsion, and adhesion. Ephrin-A3/EFNA3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Ephrin-A3/EFNA3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin-A3/EFNA3 Protein, Mouse (HEK293, His) is 183 a.a., with molecular weight of ~38 kDa.

研究背景

Ephrin-A3/EFNA3 蛋白是一种细胞表面 GPI 结合配体,通过与 Eph 受体(参与迁移、排斥和粘附的受体酪氨酸激酶家族)相互作用,在神经元、血管和上皮发育中发挥关键作用。它与相邻细胞上的 Eph 受体混杂结合,启动接触依赖性双向信号传导。受体的下游信号传导称为正向信号传导,而肝配蛋白配体的下游信号传导称为反向信号传导。Ephrin-A3/EFNA3 还与 EPHA8 相互作用并激活该受体,进一步促进其调节功能。

生物活性

Measured by its ability to inhibit proliferation of PC-3 human prostate cancer cells. The ED50 for this effect is 17.91 ng/mL, corresponding to a specific activity is 5.58×104 units/mg.

  • Measured by its ability to inhibit proliferation of PC-3 human prostate cancer cells. The ED50 for this effect is 17.91 ng/mL, corresponding to a specific activity is 5.58×104 units/mg.
种属

Mouse

表达系统

HEK293

标签

C-His

蛋白编号

O08545 (Q23-S205)

基因 ID

13638  [NCBI]

蛋白结构
N-term
EFNA3 (Q23-S205)
Accession # O08545
His
C-term
同用名
Ephrin-A3; EFL-2; EHK1-L; LERK-3; EFNA3; EFL2; EPLG3
氨基酸序列

QGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGPGGGAEQYVLYMVNLSGYRTCNASQGSKRWECNRQHASHSPIKFSEKFQRYSAFSLGYEFHAGQEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSIS

分子量

Approximately 38 kDa

纯度
  • Greater than 90% as determined by reducing SDS-PAGE.
性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

Ephrin-A3/EFNA3 Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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