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  3. T Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins Fc-gamma Receptor
  4. FcγRIIIB/CD16b CLM-7/CD300b Fc gamma RIII/CD16
  5. Fc gamma RIIIB/CD16b 蛋白, Human (NA2, HEK293, His-Avi)

Fc gamma RIIIB/CD16b 蛋白, Human (NA2, HEK293, His-Avi)

目录号: HY-P78438
产品使用指南

Fc gamma RIIIB/CD16b 蛋白是 IgG 的低亲和力受体,可结合复合或单体 IgG。与 Fc gamma RIIIA 不同,它不能介导抗体依赖性细胞毒性或吞噬作用。相反,Fc gamma RIIIB 可能充当免疫复合物的陷阱,在不激活中性粒细胞的情况下进行循环。它作为单体存在,与 INPP5D/SHIP1 相互作用,这意味着它在与免疫反应相关的细胞内信号传导途径中发挥作用。Fc gamma RIIIB/CD16b 蛋白, Human (NA2, HEK293, His-Avi) 是重组的 Fc gamma RIIIB/CD16b 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。Fc gamma RIIIB/CD16b 蛋白, Human (NA2, HEK293, His-Avi) 全长 184 个氨基酸,分子量为 47-53 kDa。

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描述

Fc gamma RIIIB/CD16b Protein, a low-affinity receptor for IgG, binds complexed or monomeric IgG. Unlike Fc gamma RIIIA, it cannot mediate antibody-dependent cytotoxicity or phagocytosis. Instead, Fc gamma RIIIB may act as a trap for immune complexes, circulating without activating neutrophils. Existing as a monomer, it interacts with INPP5D/SHIP1, implying its role in intracellular signaling pathways linked to immune responses. Fc gamma RIIIB/CD16b Protein, Human (NA2, HEK293, His-Avi) is the recombinant human-derived Fc gamma RIIIB/CD16b protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of Fc gamma RIIIB/CD16b Protein, Human (NA2, HEK293, His-Avi) is 184 a.a., with molecular weight of 47-53 kDa.

研究背景

Fc gamma RIIIB/CD16b 蛋白充当免疫球蛋白 gamma Fc 区的受体,表现出低亲和力并与复合或聚集的 IgG 以及单体 IgG 结合。与 Fc γ RIIIA 相比,Fc γ RIIIB 缺乏介导抗体依赖性细胞毒性和吞噬作用的能力。相反,它可能充当外周循环免疫复合物的陷阱,而不激活中性粒细胞。该蛋白以单体形式存在,并与 INPP5D/SHIP1 相互作用,表明其参与与免疫反应相关的细胞内信号传导途径。

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

O75015 (G17-S200)

基因 ID
蛋白结构
N-term
CD16b (G17-S200)
Accession # O75015
His-Avi
C-term
同用名
CD16; Fc gamma RIIIB; FCG3; Fc-gamma receptor IIIb (CD 16); Fc-gamma RIIIb; Fc-gamma RIII-beta; FCGR3B; FcgRIIIB; FCRIIIB; IGFR3; IgG Fc receptor III-1; CD16b (NA2); CD16B; FCG3B; FCG3; FCGR3; FCR-10; Fc-gamma RIII-β
分子量

47-53 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Fc gamma RIIIB/CD16b Protein, Human (NA2, HEK293, His-Avi)
目录号:
HY-P78438
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