FCAR/CD89 蛋白, Rat (HEK293, His)

FCAR is an Fc fragment of the IgA receptor, also known as CD89. Fcars are found on the cell surface of myeloid cells, including neutrophils, monocytes, macrophages, and eosinophils. FCAR exerts proinflammatory effects by participating in PI3K and PLC-γ signaling. FCAR is also an important Fc receptor for neutrophils to kill tumor cells. FCAR/CD89 Protein, Rat (HEK293, His) is the recombinant rat-derived FCAR/CD89 protein, expressed by HEK293 , with C-His labeled tag. The total length of FCAR/CD89 Protein, Rat (HEK293, His) is 207 a.a., with molecular weight of 35-40 kDa.

IgA 受体 Fc 片段 (Fc fragment of IgA receptor, FCAR) 编码跨膜受体 FcαRI，也称为 CD89。FCAR 存在于髓系细胞的细胞表面，包括中性粒细胞、单核细胞、巨噬细胞和嗜酸性粒细胞。FCAR 在促炎和抗炎反应中均发挥作用，这取决于其与 IgA 的结合状态。FCAR 通过参与 PI3K和 PLC-γ 信号传导发挥促炎作用。FCAR 也是嗜中性粒细胞杀伤肿瘤细胞的重要 Fc 受体。

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Rat FCAR at 1 µg/mL can bind Rat IgA with an apparent KD is 5.683 nM.

Rat

HEK293

C-His

D3ZRL6/NP_973721.1 (Q22-N228)

365183  [NCBI]

35-40 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.