FCRL6 蛋白, Human (His)

FCRL6 Protein serves as a receptor for MHC class II, interacting with HLA-DR when specific beta chains are associated. Although independent stimulation of FCRL6 doesn't contribute to cytokine production or cytotoxic activities, it exhibits tyrosine-phosphorylated interactions with proteins like PTPN11, PTPN6, INPP5D, INPPL1, and GRB2. These associations suggest FCRL6's potential regulatory role in signaling pathways involving tyrosine phosphorylation events with various cellular proteins. FCRL6 Protein, Human (His) is the recombinant human-derived FCRL6 protein, expressed by E. coli, with N-His labeled tag. The total length of FCRL6 Protein, Human (His) is 288 a.a., with molecular weight of ~35.7 kDa.

FCRL6 蛋白充当 MHC II 类受体，当 α 链与特定 β 链结合时，FCRL6 蛋白与 HLA-DR 相互作用就证明了这一点。然而，当独立刺激时，FCRL6不会促进细胞因子的产生、NK细胞或细胞毒性CD8(+) T细胞释放细胞毒性颗粒。FCRL6 不充当 Fc 受体，但与 PTPN11、PTPN6、INPP5D、INPPL1 和 GRB2 等蛋白质表现出相互作用，特别是酪氨酸磷酸化相互作用。这些关联强调了 FCRL6 在涉及各种细胞蛋白的酪氨酸磷酸化事件介导的信号通路中的潜在调节作用。

Human

E. coli

N-His

Q6DN72 (L20-W307)

343413  [NCBI]

LYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNW

Approximately 35.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.