FES 蛋白, Human (sf9, His-GST)

FES, a tyrosine-protein kinase, regulates cellular processes, including actin dynamics and cell spreading. It influences FCER1-mediated signaling in mast cells, KIT receptor pathways, and NGF-induced neurite outgrowth. FES contributes to HGF-triggered cell scattering and migration, phosphorylating proteins like BCR and HCLS1/HS1, impacting cellular signaling pathways. FES Protein, Human (sf9, His-GST) is the recombinant human-derived FES protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of FES Protein, Human (sf9, His-GST) is 822 a.a., with molecular weight of ~110 kDa.

FES 是一种酪氨酸蛋白激酶，在细胞表面受体下游发挥作用，有助于调节各种细胞过程，包括肌动蛋白细胞骨架动力学、微管组装、细胞附着和细胞扩散。它在肥大细胞中 FCER1 介导的信号传导中发挥着至关重要的作用，影响肥大细胞脱粒，并作用于 KIT 受体的下游。此外，FES 还参与细胞分化，响应 NGF 信号传导促进神经突生长。它有助于 HGF 诱导的 EZR 激活引发的细胞分散和迁移。FES 磷酸化 BCR 等关键蛋白，导致 BCR 激酶活性以及 HCLS1/HS1、PECAM1、STAT3 和 TRIM28 下调，强调其在细胞信号通路中的多种调节功能。

Human

Sf9 insect cells

N-His;N-GST

P07332-1 (M1-R822)

2242  [NCBI]

MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR

Approximately 110 kDa

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.