1. 重组蛋白
  2. Cytokines and Growth Factors
  3. FGF Family
  4. Fibroblast Growth Factor
  5. FGF-23
  6. FGF-23 蛋白, Rat (His)

FGF-23 蛋白, Rat (His)

目录号: HY-P72195
COA 产品使用指南

FGF-23 蛋白是磷酸盐稳态的关键调节剂,并通过降低 SLC34A1 水平来抑制肾小管磷酸盐转运。它还调节维生素 D 代谢,负向调节成骨细胞分化和基质矿化,并减少甲状旁腺分泌甲状旁腺激素。FGF-23 蛋白, Rat (His) 是重组的 FGF-23 蛋白,由 E. coli 表达,带有 N-6*His 标签。FGF-23 蛋白, Rat (His) 全长 227 个氨基酸,分子量约为 ~29.5 kDa。

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2 μg ¥380 In-stock
10 μg ¥1070 In-stock
50 μg ¥3000 In-stock
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描述

FGF-23 protein is a key regulator of phosphate homeostasis and inhibits renal tubular phosphate transport by reducing SLC34A1 levels. It also modulates vitamin D metabolism, negatively regulates osteoblast differentiation and matrix mineralization, and reduces parathyroid hormone secretion from the parathyroid glands. FGF-23 Protein, Rat (His) is the recombinant rat-derived FGF-23 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FGF-23 Protein, Rat (His) is 227 a.a., with molecular weight of ~29.5 kDa.

研究背景

FGF-23 蛋白是磷酸盐稳态的关键调节剂,通过降低 SLC34A1 水平抑制肾小管磷酸盐转运来发挥其作用。此外,它还具有调节维生素 D 代谢的作用。此外,FGF-23 蛋白负向调节成骨细胞分化和基质矿化。它直接影响甲状旁腺,减少甲状旁腺激素的分泌。在 KL 存在的情况下,FGF-23 蛋白还会上调 EGR1 表达。此外,它与 FGFR1、FGFR2、FGFR3 和 FGFR4 相互作用,并且作为辅助受体的 KL 和硫酸乙酰肝素糖胺聚糖增强成纤维细胞生长因子 (FGF) 与其受体之间的亲和力。

种属

Rat

表达系统

E. coli

标签

N-6*His

蛋白编号

Q8VI82 (Y25-V251)

基因 ID

170583  [NCBI]

蛋白结构
N-term
6*His
FGF-23 (Y25-V251)
Accession # Q8VI82
C-term
同用名
Fgf23Fibroblast growth factor 23; FGF-23
氨基酸序列

YSDTSPLLGSNWGSLTHLYTATARNSYHLQIHRDGHVDGTPHQTIYSALMITSEDAGSVVIIGAMTRRFLCMDLRGNIFGSYHFSPENCRFRQWTLENGYDVYLSPKHHYLVSLGRSKRIFQPGTNPPPFSQFLARRNEVPLLHFYTARPRRHTRSAEDPPERDPLNVLKPRPRATPIPVSCSRELPSAEEGGPAASDPLGVLRRGRGDARRGAGGTDRCRPFPRFV

分子量

Approximately 29.5 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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FGF-23 Protein, Rat (His)
目录号:
HY-P72195
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