GDF-15 蛋白, Canine (His)

The GDF-15 Protein, a significant TGF-beta family member, plays a crucial role in cell growth, differentiation, and immune regulation. Its study enhances understanding of signaling pathways associated with the TGF-beta superfamily and provides insights into its unique contributions to cellular homeostasis. GDF-15's classification within the TGF-beta family underscores its specific role among growth factors. Further exploration promises to enhance our knowledge of its contributions to both normal physiology and disease states, offering potential applications in cancer research, inflammation, and metabolic disorders. GDF-15 Protein, Canine (His) is the recombinant canine-derived GDF-15 protein, expressed by E. coli, with N-His labeled tag. The total length of GDF-15 Protein, Canine (His) is 111 a.a., with molecular weight of 15-20 kDa under reduced (R) condition & 23-26 kDa under Non reduced (N) condition., respectively.

GDF-15 蛋白是 TGF-β 家族的重要成员，强调了其在细胞生长、分化和免疫调节等多种细胞过程中的关键作用。作为该家族的一部分，GDF-15 可能与相关蛋白具有保守的结构和功能特征，强调其参与与 TGF-β 超家族相关的信号通路。TGF-β家族的分类强调了其在更广泛的生长因子背景下的特定名称，提供了对其对细胞稳态的独特贡献的见解。GDF-15 的研究有助于我们了解其在各种生理和病理条件下的作用，并为癌症研究、炎症和代谢紊乱提供潜在的应用。对 GDF-15 作用的进一步探索有望增强我们对其对正常生理和疾病状态的贡献的了解。

1. Immobilized Canine GDF15, His Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-GDF15 Antibody, hFc Tag with the EC₅₀ of 6.7 ng/ml determined by ELISA.
2. Immobilized Canine GDF15, His Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Human GFRAL, hFc Tag with the EC₅₀ of 48.3 ng/mL determined by ELISA.

Canine

E. coli

N-His

A0A8C0TNP6 (A197-V307)

484822  [NCBI]

ARDGCPLGEGRCCRLQSLRASLQDLGWANWVVAPRELDVRMCVGACPSQFRSANTHAQMQARLHGLNPDAAPAPCCVPASYEPVVLMHQDSDGRVSLTPFDDLVAKDCHCV

15-20 kDa under reduced (R) condition & 23-26 kDa under Non reduced (N) condition.

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of 50 mM HAc, pH 2.9. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in 50mM HAc, pH 2.9.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.