Latent GDF-8 蛋白, Human (HEK293, His)

GDF-8 (Growth Differentiation Factor 8) functions as a specific negative regulator of skeletal muscle growth. It forms homodimers linked by disulfide bonds and inhibits WFIKKN2 activity through interaction. GDF-8 also interacts with FST3, playing a regulatory role in skeletal muscle growth modulation. Latent GDF-8 Protein, Human (HEK293, His) is the recombinant human-derived Latent GDF-8 protein, expressed by HEK293, with N-His labeled tag.

GDF-8（生长分化因子 8）是骨骼肌生长的特定负调节因子。它形成通过二硫键连接的同二聚体并与 WFIKKN2 相互作用，从而抑制后者的活性。此外，GDF-8 与 FST3 相互作用，有助于发挥其在调节骨骼肌生长中的调节作用。

Measured by its binding ability in a functional ELISA. Immobilized Human Latent GDF-8, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GDF8 Antibody, hFc Tag with the EC₅₀ of ≤21.5 ng/ml determined by ELISA.

Human

HEK293

N-His

O14793 (N24-S375)

2660

Full Length of Mature Protein (with Propeptide)

NENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

Approximately 35-40 kDa & 45-55 kDa, based on SDS-PAGE under reducing conditions.

Greater than 95% as determined by reducing Bis-Tris PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, 200mM L­Arginine (pH 7.4).

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.