1. 重组蛋白
  2. Cytokines and Growth Factors Biotinylated Proteins
  3. TGF-beta Superfamily Neurotrophic Factors
  4. GDNF family
  5. GFRAL 蛋白, Cynomolgus (HEK293, His-Avi)

GFRAL 蛋白, Cynomolgus (HEK293, His-Avi)

目录号: HY-P77683
产品使用指南

GFRAL 蛋白是 GDF15 的脑干限制性受体,可调节食物摄入、能量消耗和体重,以应对代谢和毒素引起的压力。GFRAL 与其配体 GDF15 结合,与 RET 相互作用,并激活 MAPK 和 AKT 信号通路。GFRAL 蛋白, Cynomolgus (HEK293, His-Avi) 是重组的 GFRAL 蛋白,由 HEK293 表达,带有 N-His, N-Avi 标签。GFRAL 蛋白, Cynomolgus (HEK293, His-Avi) 全长 332 个氨基酸,分子量为 50-70 kDa。

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描述

The GFRAL protein is a brainstem-restricted receptor for GDF15 that regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stress. GFRAL binds to its ligand GDF15, interacts with RET, and activates the MAPK and AKT signaling pathways. GFRAL Protein, Cynomolgus (HEK293, His-Avi) is the recombinant cynomolgus-derived GFRAL protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of GFRAL Protein, Cynomolgus (HEK293, His-Avi) is 332 a.a., with molecular weight of 50-70 kDa.

研究背景

GFRAL 蛋白是 GDF15 的脑干限制性受体,在调节食物摄入、能量消耗和体重以应对代谢和毒素引起的压力方面发挥着至关重要的作用。在与其配体 GDF15 结合后,GFRAL 与 RET 相互作用,并通过 MAPK 和 AKT 信号通路激活细胞信号传导。该受体通过其胞外结构域与 GDF15 和 RET 形成复合物,在 GDF15 结合后 RET 参与时特异性介导细胞信号传导。这种复杂的相互作用凸显了 GFRAL、GDF15 和 RET 在调节代谢挑战的生理反应中的连续步骤。

种属

Cynomolgus

表达系统

HEK293

标签

N-His;N-Avi

蛋白编号

XP_015304775 (Q20-E351)

基因 ID

102126381  [NCBI]

蛋白结构
N-term
His-Avi
GFRAL (Q20-E351)
Accession # XP_015304775
C-term
同用名
GFR alpha-like; GFRAL; GRAL; C6orf144
分子量

50-70 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
GFRAL Protein, Cynomolgus (HEK293, His-Avi)
目录号:
HY-P77683
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