HABP2 蛋白, Human (HEK293, His)

HABP2 is a protein that cleaves the alpha chain of fibrinogen as well as the beta chain between "Lys-53" and "Lys-54" at multiple sites, preventing direct formation of a fibrin clot. It activates coagulation factor VII and converts prourokinase into its active form. HABP2 Protein, Human (HEK293, His) is the recombinant human-derived HABP2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HABP2 Protein, Human (HEK293, His) is 256 a.a., with molecular weight of 35-40 kDa.

HABP2 是一种多功能蛋白，通过在纤维蛋白原的多个位点裂解 α 链以及“Lys-53”和“Lys-54”之间的 β 链而表现出蛋白水解活性，同时保留 γ 链，从而防止直接启动纤维蛋白凝块的形成和纤维蛋白溶解。值得注意的是，HABP2 不会激活凝血酶原和纤溶酶原，但会促进尿激酶原转化为其活性双链形式。此外，它还可作为凝血因子 VII 的激活剂。除了止血作用外，HABP2 还可以充当肿瘤抑制因子，对细胞增殖和迁移发挥负调节作用。在结构上，HABP2 作为异二聚体存在，具有通过二硫键连接的 50 kDa 重链和 27 kDa 轻链。

Human

HEK293

C-6*His

Q14520-1 (F24-Q279)

3026  [NCBI]

FSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPCGRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQ

35-40 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.