2. 重组蛋白
  3. Viral Proteins
  4. Influenza Viruses Proteins
  5. Influenza Hemagglutinin
  6. HA/Hemagglutinin 蛋白, H5N1 (Q207Z6, sf9, His)

HA/Hemagglutinin 蛋白, H5N1 (Q207Z6, sf9, His)

目录号: HY-P75031
产品使用指南

HA/血凝素蛋白附着于唾液酸受体，通过网格蛋白依赖性或非依赖性途径启动病毒内化。它至关重要地决定宿主范围和毒力，介导内吞病毒颗粒膜和内体膜之间作为 I 类病毒融合蛋白的融合。在低pH内体环境中，HA2经历不可逆的构象变化，释放融合疏水肽。多个 HA 三聚体对于有能力的融合孔至关重要。它在受体结合、内化、融合和膜穿透中的作用塑造了病毒的特征。HA/Hemagglutinin 蛋白, H5N1 (Q207Z6, sf9, His) 是重组的 HA/血凝素蛋白，由 Sf9 昆虫细胞表达，带有 C-His 标签。HA/Hemagglutinin 蛋白, H5N1 (Q207Z6, sf9, His) 全长 531 个氨基酸，分子量约为 ~60.1 kDa。

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描述

The HA/Hemagglutinin Protein attaches to sialic acid receptors, initiating virus internalization via clathrin-dependent or -independent pathways. It crucially determines host range and virulence, mediating fusion between the endocytosed virus particle's membrane and the endosomal membrane as a Class I viral fusion protein. In the low pH endosome environment, HA2 undergoes an irreversible conformational change, releasing the fusion hydrophobic peptide. Multiple HA trimers are essential for a competent fusion pore. Its roles in receptor binding, internalization, fusion, and membrane penetration shape viral characteristics. HA/Hemagglutinin Protein, H5N1 (Q207Z6, sf9, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of HA/Hemagglutinin Protein, H5N1 (Q207Z6, sf9, His) is 531 a.a., with molecular weight of ~60.1 kDa.
研究背景

HA/血凝素蛋白与细胞表面上含唾液酸的受体结合，促进病毒颗粒附着到细胞上。这种附着通过网格蛋白依赖性内吞作用或网格蛋白和小窝蛋白独立途径触发病毒粒子的内化。它对于确定病毒的宿主范围限制和毒力具有重要作用。作为I类病毒融合蛋白，它负责介导内吞病毒颗粒膜与内体膜的融合，使病毒进入细胞胞质。在内体的低pH环境下，HA2发生不可逆的构象变化，导致融合疏水肽的释放。多个HA三聚体对于形成有能力的融合孔是必需的。
种属

Virus
表达系统

Sf9 insect cells
标签

C-His
蛋白编号

Q207Z6 (M1-Q531)
基因 ID

/
蛋白结构
N-term
H5N1 HA (M1-Q531)
Accession # Q207Z6
His
C-term
同用名
Influenza A H5N1 (A/turkey/Turkey/1/2005) Hemagglutinin / HA Protein (sf9, His)
分子量

Approximately 60.1 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

HA/Hemagglutinin Protein, H5N1 (Q207Z6, sf9, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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