HYOU1 蛋白, Human (HEK293, His)

The HYOU1 protein plays a crucial role in coordinating cytoprotective mechanisms in response to hypoxia, indicating its importance in cellular stress responses. It involves a potential molecular chaperone function and is actively involved in the protein folding process. HYOU1 Protein, Human (HEK293, His) is the recombinant human-derived HYOU1 protein, expressed by HEK293 , with C-10*His labeled tag.

HYOU1 蛋白错综复杂地参与缺氧期间激活的重要细胞保护反应，强调了其在细胞适应缺氧条件中的关键作用。此外，HYOU1 可能充当分子伴侣，有助于蛋白质折叠过程。它是一个重要的伴侣多蛋白复合物的组成部分，该复合物包括 DNAJB11、HSP90B1、HSPA5、PDIA2、PDIA4、PDIA6、PPIB、SDF2L1、UGGT1 和少量的 ERP29，而 CALR 和 CANX 要么不存在，要么以非常低的水平存在于这个复杂的。这些发现强调了 HYOU1 在协调细胞对缺氧反应的重要性及其在蛋白质质量控制机制中的潜在参与。

Measured by ATPase activity using a Malachite Green assay. The specific activity is 1633.88 pmol/min/μg.

Human

HEK293

C-10*His

Q9Y4L1-1 (M695-L999)

10525  [NCBI]

Partial

MVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKVETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL

Approximately 53-75 kDa, due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.