IGF2R 蛋白, Human (HEK293, His-Avi)

IGF2R Protein orchestrates cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes, with phosphomannosyl residues, bind to mannose-6-phosphate receptors in the Golgi, forming a complex transported to an acidic prelysosomal compartment. The low pH facilitates complex dissociation, and the receptor is recycled via interaction with the retromer. IGF2R also binds IGF2, positively regulates T-cell coactivation with DPP4, and engages with HA-I and HA-II plasma membrane adapters, showcasing its versatile molecular interactions in intracellular transport. IGF2R Protein, Human (HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IGF2R Protein, Human (HEK293, His-Avi) is 1462 a.a., with molecular weight of 165-200 kDa.

IGF2R 蛋白是细胞过程中的关键介质，协调磷酸化溶酶体酶从高尔基复合体和细胞表面到溶酶体的运输。携带磷酸甘露糖基残基的溶酶体酶特异性结合高尔基体中的甘露糖-6-磷酸受体，形成受体-配体复合物，该复合物被转运至酸性前溶酶体区室。该区室中的低 pH 值有利于复合物的解离，之后受体被循环回高尔基体，通过其与逆转录体的相互作用进一步运输。此外，IGF2R 与 IGF2 结合，并通过直接与 DPP4 相互作用作为 T 细胞共激活的正调节因子。该蛋白质进一步与 HA-I 和 HA-II 质膜接头结合，展示了其多功能的分子相互作用。它与异三聚体逆转录体货物选择性复合物的结合凸显了它参与从内体到高尔基体的逆行运输，强调了它在细胞内运输和细胞稳态中的重要作用。

Human

HEK293

C-Avi;C-His

P11717 (E47-M1508)

3482  [NCBI]

165-200 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.