1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-17
  5. IL-17A
  6. IL-17A 蛋白, Human (HEK293)

IL-17A 蛋白是一种重要的效应细胞因子,对于先天免疫和适应性免疫防御微生物和维持组织完整性至关重要。它通过IL17RA-IL17RC异二聚体受体复合物发挥作用,触发信号通路,激活免疫相关基因转录并促进强烈的免疫炎症。IL-17A 蛋白, Human (HEK293) 是重组的 IL-17A 蛋白,由 HEK293 表达,不带标签。

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描述

The IL-17A protein is an important effector cytokine that is critical in both innate and adaptive immunity to defend against microorganisms and maintain tissue integrity. It acts through the IL17RA-IL17RC heterodimeric receptor complex, triggering signaling pathways, activating immune-related gene transcription and promoting strong immune inflammation. IL-17A Protein, Human (HEK293) is the recombinant human-derived IL-17A protein, expressed by HEK293, with tag free.

研究背景

IL-17A 蛋白是先天性和适应性免疫反应中重要的效应细胞因子,在抗菌防御和组织完整性维护中发挥着至关重要的作用。它通过 IL17RA-IL17RC 异二聚体受体复合物运作,触发下游信号通路,导致免疫相关基因的转录激活和潜在的强烈免疫炎症。作为 Th17 细胞的标志性效应细胞因子,它诱导中性粒细胞在感染部位活化和募集,有助于宿主防御细胞外细菌和真菌。此外,异二聚体参与生发中心形成,介导趋化性,并在稳态和感染期间的上皮屏障维持中发挥重要作用。它形成同二聚体和异二聚体,展示了其在协调不同免疫过程中的多功能性。IL-17A 蛋白在连接 T 细胞介导的适应性免疫与急性炎症反应方面发挥着关键作用,突显了其在免疫调节和细胞稳态中的多方面作用。

种属

Human

表达系统

HEK293

标签

Tag Free

蛋白编号

Q16552-1 (G24-A155)

基因 ID

3605

蛋白结构
N-term
IL-17A (G24-A155)
Accession # Q16552-1
C-term
蛋白长度

Full Length of Isoform-1 Mature Protein

同用名
Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17
预测分子量
15.1 kDa
分子量

Approximately 16 kDa & 17 kDa & 19 kDa,based on SDS-PAGE under reducing conditions,27-34 kDa,based on SDS-PAGE under non-reduced conditions,due to the glycosylation.

糖基化修饰
Yes
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

IL-17A Protein, Human (HEK293) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IL-17A Protein, Human (HEK293)
目录号:
HY-P704386
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