1. 重组蛋白
  2. Cytokines and Growth Factors CD Antigens
  3. Interleukin & Receptors Epithelial cell CD Proteins Endothelial cell CD Proteins
  4. IL-17 Receptor CD217
  5. IL-17RA
  6. IL-17RA 蛋白, Human (HEK 293, hFc)

IL-17RA 蛋白, Human (HEK 293, hFc)

目录号: HY-P71963
COA 产品使用指南

IL-17RA (白细胞介素 17 受体 A) 是 IL-17A 和 IL-17F 的受体,是一种 I 型膜糖蛋白。它普遍表达并表现出广泛的组织分布,并在许多炎症和自身免疫性疾病中发挥作用。IL-17RA 是IL-17 家族其他成员的共同受体亚基。IL-17RA 与 IL-17RC 结合形成 IL-17A 和 IL-17F 的信号受体复合物。IL-17RA 蛋白, Human (HEK 293, hFc) 在 HEK293 细胞中产生,由 288 个氨基酸 (L33-W320) 组成,其 C 末端带有 hFc 标签。

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规格 价格 是否有货 数量
2 μg ¥470 In-stock
10 μg ¥1200 In-stock
50 μg ¥3250 In-stock
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250 μg   询价  

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描述

IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F[1][2]. IL-17RA Protein, Human (HEK 293, hFc) is produced in HEK293 cells with a C-Terminal hFc-tag. It consists of 288 amino acids (L33-W320).

研究背景

Interleukin-17 receptor A (IL-17RA), also known as CD217, is a cytokine receptor that binds interleukin 17. IL-17RA is a proinflammatory cytokine secreted by activated T-lymphocytes. IL-17 receptor family is composed of five members from IL-17RA to IL-17RE. The subunit IL-17RA is ubiquitous and is a common co-receptor subunit for other members of the IL-17 family. The IL-17RA gene is mapped to human chromosome 22q11.1 and is expressed ubiquitously and exhibits a broad tissue distribution[1][2].
The amino acid sequence of human IL17RA protein has low homology between mouse and rat IL-17A protein.
IL-17A, the prototypic T helper 17 (Th17) cytokine, is important in host defense at mucosal surfaces, but also functions as an important inflammatory mediator involved in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). IL-17RA pairs with IL-17RC to bind either IL-17A or IL-17F as covalent homodimers, but also IL-17A/IL-17F as heterodimers. IL-17RA offers protection against pathogenic infection as it plays an important role in host defence mechanism. IL-17A activates downstream cellular signaling through IL-17 receptor (IL-17R) complex comprised of the IL-17A receptor (IL-17RA) and IL-17C receptor (IL-17RC) subunits with higher affinity to IL-17RA. The IL-17A/IL-17RA axis has been implicated in the pathogenesis of several acute and chronic airway and lung diseases. However, the association of IL-17RA with other members of the IL-17 receptor family shifts the affinity toward other members of the IL-17 family. Indeed, combination of IL-17RA with IL-17RB binds IL-17E as covalent homodimers. Besides, IL-17RA can also associate with IL-17RE to bind IL-17C as homodimers. However, the involvement of IL-17RA is not compulsory, as IL-17RB forms homodimers to target IL-17B as covalent homodimers[1][2][3].
IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL-17RA involved in antimicrobial host defense and maintenance of tissue integrity. It has been demonstrated in infectious models in which neutrophils are crucial for host defense, that IL-17RA deficiency results in reduced chemokine levels and reduced neutrophil numbers, and increased susceptibility to infection. In addition, IL-17RA is expressed by diverse intestinal cell types, and therapies targeting IL-17A induce adverse intestinal events, suggesting additional tissue-specific functions. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5). IL17RA deficiency might lead to the risk of chronic mucocutaneous candidiasis[1][2][3][4].

体外研究
(In Vitro)

IL-17RA Protein, Human (10 μg/mL; 72 hours) preincubated with IL-2 plus IL-25 for 30 min before addition to the PBMC cultures, the result shows IL-17RA does not inhibit IL-5 production in response to stimulation by IL-25 plus IL-2[5].

生物活性

The ED50 as determined by its ability to inhibit IL-17-induced IL-6 secretion by NIH3T3 mouse embryonic fibroblast cells is less than 200 ng/mL.

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

Q96F46 (L33-W320)

基因 ID

23765  [NCBI]

中文名
重组人白细胞介素-17RA (HEK 293, hFc)
同用名
CANDF5; CD217; CD217 antigen; CDw217; CTLA8; HIL 17R; hIL17R; I17RA_HUMAN; IL 17 receptor A; IL 17 receptor; IL 17RA; IL-17 receptor A; IL-17RA; IL17; IL17A receptor; IL17R; IL17RA; IMD51; Interleukin 17 receptor A; Interleukin-17 receptor A; MGC10262
氨基酸序列

LRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLW

分子量

Approximately 70.0 kDa

纯度
  • Greater than 90% as determined by reducing SDS-PAGE.
性状

Lyophilized powder.

组分

Lyophilized from a 0.2 μm solution of 1xPBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in sterile distilled water.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料
参考文献
  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IL-17RA Protein, Human (HEK 293, hFc)
目录号:
HY-P71963
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