IL-1RAcP/IL-1 R3 蛋白, Mouse (HEK293, Fc)

IL-1RAcP is a co-receptor for IL1RL2, IL1R1 and IL1RL1 in the IL-36, IL-1 and IL-33 signaling system, respectively. IL-1RAcP is an essential component of the IL-1 receptor and plays an essential role in the inflammatory process^[1][2]. IL-1RAcP/IL-1 R3 Protein, Mouse (HEK293, Fc) is a recombinant mouse IL-1RAcP protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 350 amino acids (M1-K350).

白细胞介素1受体辅助蛋白（IL-1RAcP），也称为IL-1 R3，属于免疫球蛋白（Ig）超家族。IL-1RAcP 可在肝脏、皮肤、胎盘、胸腺和肺中检测到。IL-1RAcP 表达与小鼠淋巴瘤细胞系 EL4 亚克隆中的 IL-1 反应性相关。
小鼠 IL-1RAcP 蛋白与人类有 89.12% 的氨基酸序列同一性，与大鼠有 95.09% 的氨基酸序列同一性。
IL-1RAcP 包含三个 Ig 样结构域和一个名为 Toll/IL-1 受体 (TIR)（位置：403-546 aa）的胞质结构域，该结构域与信号转导有关。IL-1RAcP 还包含单个跨膜区。IL-1RAcP 分别是 IL-36、IL-1 和 IL-33 信号系统中 IL1RL2、IL1R1 和 IL1RL1 的共受体。IL-1RAcP 是 IL-1 受体信号转导复合物中不可或缺的分子，将质膜水平的事件与下游信号通路联系起来，介导 IL-1 依赖性转录因子激活和基因表达。
IL-1RAcP 发挥着重要作用在炎症过程中发挥重要作用，可用于肥胖、糖尿病、子宫内膜异位症、动脉粥样硬化等的研究^[1][2][3]。

Mouse

HEK293

C-hFc

Q61730 (M1-K350)

16180  [NCBI]

Approximately 65 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Neveu PJ, et al. Mechanisms of behavioral and neuroendocrine effects of interleukin-1 in mice. Ann N Y Acad Sci. 2000;917:175-85.  [Content Brief]

  [2]. Zarezadeh Mehrabadi A, et al. The roles of interleukin-1 receptor accessory protein in certain inflammatory conditions. Immunology. 2022 May;166(1):38-46.  [Content Brief]

  [3]. Wesche H, et al. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J Biol Chem. 1997 Mar 21;272(12):7727-31.  [Content Brief]