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  5. IL-3 蛋白, Human

IL-3 蛋白, Human

目录号: HY-P7040
COA 产品使用指南

IL-3 蛋白, Human是一种造血细胞因子,对血小板和中性粒细胞计数具有良好效果,对继发性造血功能衰竭具有治疗效果。

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重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
Free Sample   Apply now  
2 μg ¥400 In-stock
10 μg ¥1070 In-stock
50 μg ¥3000 In-stock
100 μg   询价  

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  • 生物活性

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  • 产品资料

  • 参考文献

描述

IL-3 Protein, Human is a multilineage hematopoietic cytokine with promising effects on platelet and neutrophil counts and special usefulness in patients with secondary hematopoietic failure.

研究背景

白细胞介素-3 (IL-3) 是属于造血生长因子家族的糖蛋白,在临床前体外和体内研究中已表现出多谱系活性。重组人白细胞介素 3 (rhIL-3) 通过重组人粒细胞集落刺激因子 (rhG-CSF) 增强外周血祖细胞的动员[1]。人白细胞介素 3 (hIL-3) 是一种多能造血细胞因子,由有丝分裂原和抗原激活的角质形成细胞、T 淋巴细胞、肥大细胞、NK 细胞、单核细胞和内皮细胞产生。造血祖细胞在hIL-3蛋白的帮助下增殖并分化为成熟红细胞、肥大细胞、巨核细胞和粒细胞。hIL-3 蛋白的潜在用途已在骨髓移植、血液恶性肿瘤、血细胞减少症、再生障碍性贫血和各种类型的癌症等各种临床应用中得到广泛测试[2]

生物活性

The ED50 is <0.6 ng/mL as measured by TF-1 cells, corresponding to a specific activity of >1.67 × 107 units/mg.

  • The ED50 is <0.5 ng/mL as measured by measured by its ability to stimulate the proliferation of TF-1 cells.
种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

P08700 (A20-F152)

基因 ID
蛋白结构
N-term
IL-3 (A20-F152)
Accession # P08700
C-term
中文名
重组人IL 3蛋白
同用名
rHuIL-3; Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor
氨基酸序列

APMTQTTPLKTSWVNCSNMIDEIITHLKQPPLPLLDFNNLNGEDQDILMENNLRRPNLEAFNRAVKSLQNASAIESILKNLLPCLPLATAAPTRHPIHIKDGDWNEFRRKLTFYLKTLENAQAQQTTLSLAIF

分子量

Approximately 15.2 kDa

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末

组分

Lyophilized after extensive dialysis against PBS or 50 mM Tris-HCL, 300 mM NaCl, 200 mM arginine, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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