KIR2DL3 蛋白, Human (HEK293, His-Avi)

KIR2DL3, found on NK cells, selectively recognizes HLA-C alleles like HLA-Cw1, HLA-Cw3, and HLA-Cw7. Its interaction leads to inhibitory effects, preventing NK cell activity and cell lysis. KIR2DL3's association with ARRB2 underscores its role in cellular signaling pathways, intricately modulating NK cell functions. KIR2DL3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived KIR2DL3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of KIR2DL3 Protein, Human (HEK293, His-Avi) is 224 a.a., with molecular weight of 45-52 kDa.

KIR2DL3 在自然杀伤 (NK) 细胞上表达，作为特异性识别 HLA-C 等位基因（例如 HLA-Cw1、HLA-Cw3 和 HLA-Cw7）的受体发挥作用。通过这种相互作用，KIR2DL3 对 NK 细胞活性产生抑制作用，在防止细胞裂解方面发挥着至关重要的作用。该受体进一步与 ARRB2 结合，突显其参与调节 NK 细胞功能的复杂细胞信号传导途径。

Human

HEK293

C-Avi;C-His

P43628 (H22-H245)

3804  [NCBI]

45-52 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.