KYNU/Kynureninase 蛋白, Human (sf9, His)

KYNU, a multifaceted enzyme, plays a pivotal role in the catabolism of tryptophan by catalyzing the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Demonstrating a preference for the L-3-hydroxy form, KYNU exhibits cysteine-conjugate-beta-lyase activity, showcasing its versatility in various metabolic pathways. KYNU/Kynureninase Protein, Human (sf9, His) is the recombinant human-derived KYNU/Kynureninase protein, expressed by Sf9 insect cells , with C-His labeled tag.

犬尿氨酸酶 (KYNU) 是一种关键酶，可催化 L-犬尿氨酸 (L-Kyn) 和 L-3-羟基犬尿氨酸 (L-3OHKyn) 分别裂解为邻氨基苯甲酸 (AA) 和 3-羟基邻氨基苯甲酸 (3-OHAA) 。值得注意的是，KYNU 在其酶活性方面表现出对 L-3-羟基形式的偏好。除了在犬尿氨酸途径中的作用外，KYNU 还表现出半胱氨酸缀合物-β-裂合酶活性，为其多功能性增加了另一层。这种酶的多功能性使 KYNU 成为色氨酸衍生化合物代谢中的关键参与者，突出了其在调节邻氨基苯甲酸和 3-羟基邻氨基苯酸等生物活性分子水平方面的重要性，并强调其更广泛地参与细胞过程。

Measured by its ability to oxidize 3-hydroxykynurenine.The specific activity is > 200 pmoles/min/μg.

Human

Sf9 insect cells

C-His

Q16719 (M1-N465)

8942  [NCBI]

Full Length

MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECF

Approximately 47 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 25% glycerol.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.