1. 重组蛋白
  2. Cytokines and Growth Factors
  3. CSF & Receptors
  4. M-CSF
  5. M-CSF 蛋白, Human

M-CSF 蛋白, Human

目录号: HY-P7050
COA 产品使用指南

M-CSF 蛋白, Human是一种造血生长因子,具有多个糖基化位点,能够影响巨噬细胞的生存和功能,同时具有抗肿瘤活性。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
Free Sample   Apply now  
2 μg ¥750 In-stock
10 μg ¥2100 In-stock
50 μg ¥5300 In-stock
100 μg ¥8400 询价
> 100 μg   询价  

* Please select Quantity before adding items.

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

  • 参考文献

描述

M-CSF Protein, Human is a hematopoietic growth factor with various glycosylation sites, affects survival and function of the tissue macrophages, and possesses antitumor activity.

研究背景

重组人巨噬细胞集落刺激因子是一种具有多种糖基化位点的造血生长因子,影响组织巨噬细胞的存活和功能,并具有抗肿瘤活性[1]。巨噬细胞集落刺激因子 (M-CSF) 是一种促炎细胞因子,由多种细胞类型组成,如成纤维细胞、内皮细胞、基质细胞、巨噬细胞、平滑肌细胞和成骨细胞,与其受体 CSF1R 结合,存在于多种亚型 - 作为分泌糖蛋白、细胞表面蛋白和蛋白聚糖[2]M-CSF 参与单核细胞/巨噬细胞谱系细胞的发育和增殖,并参与破骨细胞的诱导,破骨细胞对于骨和软骨的破坏以及类风湿性关节炎患者的关节周围骨质疏松变化非常重要[3]

生物活性

The ED50 is 0.4 - 3 ng/mL as measured by M-NFS-60 cells, corresponding to a specific activity of 3.3 × 105 - 2.5 × 106 units/mg.

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

P09603-3 (E33-S190)

基因 ID
蛋白结构
N-term
M-CSF (E33-S190)
Accession # P09603-3
C-term
中文名
重组人巨噬细胞群刺激因子
同用名
rHuM-CSF; CSF-1; MGI-IM
氨基酸序列

EEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQGHERQSEGS

分子量

19-28 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末

组分

Lyophilized from a 0.22 μm filtered solution of 50 mM Tris-HCl, pH 8.0 or 50 mM Tris-HCL, 300 mM NaCl, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS or Tris-HCl, pH 8.0. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献

M-CSF Protein, Human 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
M-CSF Protein, Human
目录号:
HY-P7050
需求量: