MDH1 蛋白, Human (His)

Multiple studies have shown that the MDH1 protein plays a crucial role in cellular metabolism, catalyzing the reduction of aromatic α-keto acids in the presence of NADH. It plays an important role in the malate-aspartate shuttle and the tricarboxylic acid cycle, which is essential for supplying mitochondrial NADH for oxidative phosphorylation. MDH1 Protein, Human (His) is the recombinant human-derived MDH1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of MDH1 Protein, Human (His) is 333 a.a., with molecular weight of ~38 kDa.

MDH1 蛋白，也称为苹果酸脱氢酶 1，在细胞代谢中发挥多方面的作用。它在 NADH 存在的情况下催化芳香族 α-酮酸的还原，这是各种代谢途径不可或缺的过程。MDH1 对于苹果酸-天冬氨酸穿梭和三羧酸循环至关重要，有助于为氧化磷酸化（细胞能量生产的关键步骤）提供线粒体 NADH。此外，MDH1 还能催化 2-酮戊二酸还原为 2-羟基戊二酸，这是一种与活性氧 (ROS) 升高相关的反应。MDH1 的复杂功能凸显了其在维持细胞氧化还原平衡、能量代谢和活性氧调节方面的重要性。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

C-6*His

P40925 (S2-A334)

4190  [NCBI]

SEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA

Approximately 38 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.