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  3. METRNL/Meteorin-like 蛋白, Human (His-SUMO)

METRNL/Meteorin-like 蛋白, Human (His-SUMO)

目录号: HY-P71569
COA 产品使用指南

METRNL/镍纹蛋白样蛋白是由运动或寒冷暴露引起的荷尔蒙变化引起的,这会增加能量消耗。运动后,它在骨骼肌中表达,而在寒冷暴露期间,它在脂肪组织中表达。METRNL/Meteorin-like 蛋白, Human (His-SUMO) 是重组的 METRNL/镍纹蛋白样蛋白,由 E. coli 表达,带有 N-SUMO, N-6*His 标签。METRNL/Meteorin-like 蛋白, Human (His-SUMO) 全长 266 个氨基酸,分子量约为 ~46.0 kDa。

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描述

METRNL/meteorin-like protein is caused by hormonal changes caused by exercise or cold exposure, which increases energy expenditure. After exercise, it is expressed in skeletal muscle, whereas during cold exposure, it is expressed in adipose tissue. METRNL/Meteorin-like Protein, Human (His-SUMO) is the recombinant human-derived METRNL/Meteorin-like protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of METRNL/Meteorin-like Protein, Human (His-SUMO) is 266 a.a., with molecular weight of ~46.0 kDa.

研究背景

METRNL/镍纹蛋白样蛋白是响应运动或暴露于寒冷引发的荷尔蒙变化而诱导的,有助于增加能量消耗。它在运动后的骨骼肌和寒冷暴露期间的脂肪组织中观察到其表达,并在血液中循环。METRNL/镍纹蛋白样蛋白通过促进白色脂肪库褐变和改善葡萄糖耐量来促进能量消耗。有趣的是,它的产热作用并不直接作用于脂肪细胞,而是涉及刺激各种免疫细胞亚型。它诱导嗜酸性粒细胞依赖性 IL4 表达增加,并促进脂肪组织巨噬细胞的替代激活,这对于增强脂肪中生热和抗炎基因程序的表达至关重要。METRNL/镍纹蛋白样蛋白对于某些寒冷诱导的生热反应至关重要,突出了其在低温代谢适应中的作用。

种属

Human

表达系统

E. coli

标签

N-SUMO;N-6*His

蛋白编号

Q641Q3 (46Q-311D)

基因 ID
蛋白结构
N-term
6*His-SUMO
METRNL (46Q-311D)
Accession # Q641Q3
C-term
同用名
Meteorin like glial cell differentiation regulator; Meteorin; glial cell differentiation regulator like; Meteorin-like protein; METRL_HUMAN; Metrnl
氨基酸序列

QYSSDRCSWKGSGLTHEAHRKEVEQVYLRCAAGAVEWMYPTGALIVNLRPNTFSPARHLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGRVQCFGLEQGGLFVEATPQQDIGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGSIQQVTHEPERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMHFGEARLGCAPRFKDFQRMYRDAQERGLNPCEVGTD

分子量

Approximately 46.0 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

METRNL/Meteorin-like Protein, Human (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
METRNL/Meteorin-like Protein, Human (His-SUMO)
目录号:
HY-P71569
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