MICB 蛋白, Human (286a.a., HEK293, His)

MICB Protein, Human (286a.a., HEK293, His) is the recombinant human-derived MICB protein, expressed by HEK293, with C-His tag.

MICB 编码一种高度糖基化的蛋白质，作为 NKG2D II 型受体的配体。结合后，该配体会触发各种免疫细胞的溶细胞反应，包括自然杀伤 (NK) 细胞、CD8 Alphata T 细胞和表达该受体的 gammadelta T 细胞。值得注意的是，MICB 是应激诱导的，并且与 MHC I 类分子具有相似性，尽管它不与 β-2-微球蛋白结合或结合肽。选择性剪接产生多个转录变体，增加了其功能库的复杂性。MICB 的表达范围广泛，在淋巴结、骨髓和各种其他组织中显着存在，强调了其在不同生理环境下的免疫反应中的作用。

Human

HEK293

C-His

NP_005922.2 (A23-T308)

4277

Approximately 45-55 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from 0.22 μm filtered solution of PBS, 0.5 M Arginine, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.