MXRA8 蛋白, Mouse (HEK293, His)

MXRA8 is a transmembrane protein that complexly regulates signaling pathways likely by interacting with the integrin ITGAV:ITGB3. It mediates heterophil-cell interactions, inhibits osteoclastogenesis through TNFSF11/RANKL and CSF1, and inhibits VEGF-induced activation of AKT and p38 MAP kinase. MXRA8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MXRA8 protein, expressed by HEK293 , with C-His labeled tag. The total length of MXRA8 Protein, Mouse (HEK293, His) is 321 a.a., with molecular weight of 42-52 kDa.

MXRA8 是一种跨膜蛋白，可能通过与整合素 ITGAV:ITGB3 的相互作用来复杂地调节各种信号传导途径。从功能上讲，MXRA8 介导异嗜性细胞间相互作用，并抑制 TNFSF11/RANKL 和 CSF1 下游的破骨细胞生成。这种抑制作用是通过减弱整合素 ITGB3 和 MAP 激酶 p38 的信号传导来实现的。此外，MXRA8在软骨形成中发挥着至关重要的作用，促进生长板软骨细胞的增殖和成熟，刺激初级纤毛的形成，并增强刺猬信号通路相关基因的表达。在血管生成中，MXRA8 通过抑制内皮细胞迁移和促进细胞凋亡以及抑制 VEGF 诱导的 AKT 和 p38 MAP 激酶激活发挥双重作用。此外，MXRA8 还会干扰 VTN 介导的整合素 ITGAV:ITGB3 信号传导和 PTK2/FAK 激活。它的参与延伸到血脑屏障的成熟和维持。MXRA8 形成顺式同二聚体，其与 ITGB3 的相互作用抑制 ITGAV:ITGB3 异二聚体的形成。这些不同的功能强调了 MXRA8 在细胞过程和组织稳态中的多方面调节作用。

Mouse

HEK293

C-His

Q9DBV4 (V20-Q340)

74761  [NCBI]

42-52 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.