2. 重组蛋白
  3. Viral Proteins
  4. Influenza Viruses Proteins
  5. Influenza Virus Neuraminidase
  6. NA/Neuraminidase 蛋白, H1N1 (P03469, HEK293, His)

NA/Neuraminidase 蛋白, H1N1 (P03469, HEK293, His)

目录号: HY-P73776
产品使用指南

NA/神经氨酸酶蛋白是一种在流感病毒表面发现的酶，负责唾液酸残基的切割。NA/神经氨酸酶蛋白的抑制是抗病毒药物的关键靶点。靶向 NA/神经氨酸酶蛋白可能通过阻止病毒释放、减少病毒传播以及潜在治疗流感感染来提供潜在的治疗干预措施。NA/Neuraminidase 蛋白, H1N1 (P03469, HEK293, His) 是重组的 NA/神经氨酸酶蛋白，由 HEK293 表达，带有 N-His 标签。NA/Neuraminidase 蛋白, H1N1 (P03469, HEK293, His) 全长 435 个氨基酸，分子量约为 ~76.6 kDa。

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描述

NA/Neuraminidase Protein, an enzyme found on the surface of influenza viruses, is responsible for the cleavage of sialic acid residues. Inhibition of NA/Neuraminidase Protein is a key target for antiviral drugs. Targeting NA/Neuraminidase Protein may provide potential therapeutic interventions by preventing viral release, reducing viral spread, and potentially treating influenza infections. NA/Neuraminidase Protein, H1N1 (P03469, HEK293, His) is the recombinant Virus-derived NA/Neuraminidase protein, expressed by HEK293 , with N-His labeled tag. The total length of NA/Neuraminidase Protein, H1N1 (P03469, HEK293, His) is 435 a.a., with molecular weight of ~76.6 kDa.
研究背景

NA/神经氨酸酶蛋白充当从病毒和细胞糖复合物中去除唾液酸残基的催化剂。它通过裂解糖基化 HA 上的末端唾液酸，帮助病毒释放，从而在病毒出芽中发挥至关重要的作用。此外，它还通过进一步去除细胞表面的唾液酸来促进病毒传播，防止自我聚集并确保在细胞之间有效传播。这种蛋白质被称为受体破坏酶，因为它从细胞受体上裂解末端唾液酸。它还可能通过裂解气道上皮细胞粘蛋白上的唾液酸部分来促进病毒侵入上呼吸道。NA 在细胞内运输过程中与脂筏相关，可能有助于出芽过程，并且也可能具有与脂筏相关的独立效应。它参与确定宿主范围对复制和毒力的限制，并且其在晚期内体/溶酶体运输中的唾液酸酶活性似乎增强病毒复制。
种属

Virus
表达系统

HEK293
标签

N-His
蛋白编号

P03469 (H36-K470)
基因 ID

/
蛋白结构
N-term
His
H1N1 NA (H36-K470)
Accession # P03469
C-term
同用名
NA; Neuraminidase; NA/Neuraminidase Protein, H1N1 (A/USSR/90/1977, HEK293, His)
分子量

Approximately 76.6 kDa
纯度

Greater than 80% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

NA/Neuraminidase Protein, H1N1 (P03469, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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